Description medications: Roxithromycin (Roxithromycin)
Synonyms: DB Rocks, Brilid, Roksibid, hydroxide, Roksimizan, Roksitem, Rulid, Rulitsid, Rulitsin, BD-Rox, Roksid, Roximisan , Roxitem, Roxybid, Rulicin, Rulid.
Semisynthetic antibiotic, similar in structure to erythromycin - erythromycin-9- [O- (2-methoxyethoxy) methyl] oxime.
It has a wide spectrum of antibacterial action. It is active against staphylococci, streptococci, meningococci, enterococci, Vibrio cholerae, Campylobacter, Chlamydia, Clostridium, Helicobacter, Legionella, Listeria, Mycoplasma, and others. It acts on the microorganisms that produce and not producing penicillinase.
It has also anti-inflammatory properties (inhibits the synthesis of cytokines).
Rapidly absorbed in the digestive tract (is acid), C max is 1,5-2 h, T ½ - 10-14 hours; well into the tissue and body fluids and will not penetrate into the cerebrospinal fluid; partially exposed biotransformation, is slowly released mostly in faeces.
Applied with respiratory tract infections, upper respiratory tract (tonsillitis, pharyngitis, sinusitis, diphtheria, whooping cough, otitis media), the genitourinary system (urethritis, except gonorrhea, endometritis, cervico-vaginitis), mouth (periodontitis, periostitis), skin and soft tissue , chronic osteomyelitis, erythema migrans, for the prevention of meningitis and other infectious diseases.
Assign inside (to food) for adults to 0.3 grams per day (1-2 admission), children - a rate of 5-8 mg / kg per day (2 admission).
To prevent infections in AIDS apply 0.3 grams 3 times per week.
The course of treatment for 5-12 days with acute respiratory diseases and upper respiratory tract to 2-2.5 months in chronic osteomyelitis.
Possible side effects: nausea, vomiting, diarrhea, abnormal liver function, exacerbation of pancreatitis, impaired vision and smell, tinnitus, candidiasis, allergic reactions, etc.
Is contraindicated in case of hypersensitivity to the macrolide antibiotic, when expressed violations of the liver, pregnancy and breastfeeding.
Product: pills to 0.05; 0.1; 0.15 and 0.3 g (N. 10).
Storage: List B.