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Description medications: Teniposide (Teniposide)

Teniposide (Teniposide).

Synonym: Vumon, Vumon.

A white crystalline powder with a gray and yellow tint. Insoluble in water, soluble in fats.

Semi-synthetic derivative of podophyllotoxin. The structure is close to etoposide. Instead of a methyl group (CH 3) 2 in position comprises a thienyl group.

Like etoposide has cytostatic (antitumor) activity.

Applied to cancer of the lung, stomach, bladder, neuroblastoma, brain tumors (in conjunction with radiation therapy), lymphoma, acute lymphoblastic leukemia, Hodgkin disease and other tumors.

Enter intravenously and into the bladder.

Intravenously administered at 50-80 mg / m2 for 5 days with a 2-week intervals, or at 100 mg / m 2 to 1.2 and 3rd days every 3 weeks, or 130-150 mg / m 2 Jan. once a week (for children) for 4 weeks.

The bladder is introduced 0.05 g (50 mg) in 50 ml of 0.9% sodium chloride solution.

There may be nausea, vomiting, leukopenia, thrombocytopenia, alopecia (reversible), violation of the liver and kidneys, and allergic reactions.

Contraindications: violation of hematopoiesis expressed by the human liver and kidneys.

Product: 1% solution of 5 ml ampoules.

Storage: List B.