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Description of the medicine: Teniposide (Teniposide)

TENIPOSIDE (Teniposide).

Synonym: Vumon, Vumon.

The crystalline powder is white with a gray and yellow tint. Insoluble in water, soluble in fats.

Semi-synthetic derivative of podophyllotoxin. The structure is close to etoposide. Instead of a methyl group (CH 3 ), position 2 contains a thienyl group.

Like etoposide, it has cytostatic (antitumor) activity.

Used for cancer of the lung, stomach, bladder, neuroblastoma, brain tumors (in combination with radiation therapy), lymphomas, acute lymphoblastic leukemia, lymphogranulomatosis and other tumors.

Enter intravenously and into the bladder.

Intravenously prescribed 50-80 mg / m 2 for 5 days with a 2-week interval, or 100 mg / m 2 on days 1.2 and 3 every 3 weeks, or 130-150 mg / m 2 1 once a week (for children) for 4 weeks.

0.05 g (50 mg) in 50 ml of 0.9% sodium chloride solution is injected into the bladder.

Possible nausea, vomiting, leukopenia, thrombocytopenia, alopecia (reversible), impaired liver and kidney function, allergic reactions.

Contraindications: violation of hematopoiesis, severe violations of the liver and kidneys.

Release form: 1% solution in ampoules of 5 ml.

Storage: List B.