Before taking the course, consult a doctor!
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Description of the medicine: Topotecan (Topotecan)
TOPOTECAN.
(S) -10 - [(Dimethylamino) methyl] -4-ethyl-4,9-dihydroxy-1H-pyrano [3ґ, 4ґ: 6,7] indolizino [1,2- b] quinoline-3,14- (4H, 12H) -dione hydrochloride.
Synonym: Gycamtin, Hycamtin.
Semisynthetic derivative of camptothecin alkaloid isolated from the stems of the bush Campotheca acuminata.
Crystalline powder. Soluble in water.
By the mechanism of action is close to irinotecan.
Applied in ovarian cancer, lung and chronic myelomonocytic leukemia.
Enter intravenously drip (within 30 minutes) at a dose of 1.5 mg / m 2 per day for 5 days with a break of 16 days (at least 4 courses).
Possible side effects: neutropenia, leukopenia, thrombocytopenia, anemia, dyspepsia, paresthesia, arthralgia, allergic reactions.
Contraindications: myelosuppression, pregnancy, lactation, children's age.
Form release: lyophilized powder for injection solutions in vials of 0.004 g (4 mg).
Storage: List B.
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