Medication Description: Indometacin (Indometacinum)
INDOMETACIN (Indometacinum) *. 1- (a pair of chlorobenzoyl) -5-methoxy-2-methylindole-3-acetic acid.
Synonyms: Indocide, Metindol, Algometacin, Articin, Artrizinal, Artrocid, Bonatol, Cidalgon, Cinodocin, Cosmocalm, Dolopas, Dolovin, Elmetacin, Fortarthrin, Inacid, Indacin, Indocid, Indometacin, Indomethacin, Indomin, Indopathin, Indopin, Indocin, Indocin, Indocin, Indometacin, Indomethacin, Indoproocin Metacen, Mataril, Matartril, Methacid, Mathindol, Metindol, Nuricon, Peralgon, Phenotacin, Rumacid, Reumadolon, Reumatin, Sadoreum, Valicent, Vellopan, etc.
Indomethacin refers to derivatives of indole acetic acid. It is one of the most active non-steroidal anti-inflammatory drugs. A strong inhibitor of prostaglandin biosynthesis. It has pronounced analgesic activity.
Indomethacin is an active anti-inflammatory agent, effective in rheumatoid arthritis, periarthritis, ankylosing spondylitis, osteoarthrosis, gout, inflammatory diseases of the connective tissue of the musculoskeletal system, thrombophlebitis and other diseases accompanied by inflammation. It is also used in nephrotic syndrome.
Indomethacin is used orally in the form of tablets or capsules of 0.025 g (25 mg) and long-acting tablets (indomethacin retard, metindol retard) containing ind75.075 g (75 mg) of indomethacin, as well as in the form of a 10% ointment (for external use).
Indomethacin is taken orally after a meal, starting usually with 0.025 g (25 mg) 2–3 times a day (adults), then, depending on tolerance, the daily dose is increased to 100–150 mg per day (in 3–4 doses).
Like other anti-inflammatory drugs, indomethacin is usually prescribed for a long time; Premature discontinuation of the drug may lead to the resumption of pain.
For relief of acute attacks of gout, indomethacin is prescribed by 0.05 g, 3 times a day, and to prevent exacerbations, by 0.025 g, 2 times a day.
Indomethacin retard (metindol retard) is taken, starting with 1 tablet (75 mg), 2 times a day (morning and evening), for 5 to 10 days; then 1 tablet per day (in the evening). The duration of treatment depends on the effectiveness and tolerability.
With the use of indomethacin possible side effects: headache, dizziness, drowsiness.
Nausea, vomiting, loss of appetite, pain in the epigastric region may occur. The drug may have an ulcerogenic effect: in some cases, ulceration in the stomach and bleeding from the gastrointestinal tract may occur.
To prevent and reduce dyspeptic symptoms, you should take the drug during or after a meal, drinking milk, use antacids. In case of allergic reactions (skin rash, etc.), anti-histamine preparations are prescribed.
The drug is contraindicated in gastric ulcer and duodenal ulcer and other ulcerative processes in the intestine and esophagus, with bronchial asthma. Do not prescribe the drug to women during pregnancy and lactation. It is necessary to warn patients about the possibility of dizziness, especially this should be taken into account when administering indomethacin to transport drivers, people working at the machines, etc.