Description of the medicine: Indomethacin (Indometacinum)
INDOMETACIN (Indometacinum) *. 1- (para-Chlorobenzoyl) -5-methoxy-2-methylindole-3-acetic acid.
Synonyms: Indocide, Metindol, Algometacin, Articin, Artrizinal, Artrocid, Bonatol, Cidalgon, Cinodocin, Cosmocalm, Dolopas, Dolovin, Elmetacin, Fortarthrin, Inacid, Indacin, Indocid, Indometacin, Indomethacin, Indomin, Indomeb, Indominite, Indopan, Indomin Indaleb, Indomethacin Metacen, Mataril, Matartril, Methacid, Mathindol, Metindol, Nuricon, Peralgon, Phenotacin, Rumacid, Reumadolon, Reumatin, Sadoreum, Valicent, Vellopan, etc.
Indomethacin is a derivative of indoleacetic acid. It is one of the most active non-steroidal anti-inflammatory drugs. Strong inhibitor of prostaglandin biosynthesis. It has a pronounced analgesic activity.
Indomethacin is an active anti-inflammatory agent effective in rheumatoid arthritis, periarthritis, ankylosing spondylitis, osteoarthritis, gout, inflammatory diseases of the connective tissue of the musculoskeletal system, thrombophlebitis and other diseases accompanied by inflammation. It is also used for nephrotic syndrome.
Indomethacin is used orally in the form of tablets or capsules of 0.025 g (25 mg) and sustained-release tablets (indomethacin retard, methindole retard) containing 0.075 g (75 mg) of indomethacin, as well as in the form of 10% ointment (for external use).
Indomethacin is taken orally after a meal, usually starting with 0.025 g (25 mg) 2–3 times a day (adults), then, depending on tolerance, increase the daily dose to 100–150 mg per day (in 3–4 doses).
Like other anti-inflammatory drugs, indomethacin is usually prescribed for a long time; premature discontinuation of the drug can lead to the resumption of pain.
To stop acute attacks of gout, indomethacin is prescribed at 0.05 g 3 times a day, and to prevent exacerbations - at 0.025 g 2 times a day.
Indomethacin retard (methindole retard) is taken starting from 1 tablet (75 mg) 2 times a day (morning and evening) for 5 to 10 days; then 1 tablet per day (in the evening). The duration of treatment depends on the effectiveness and tolerability.
When using indomethacin, side effects are possible: headache, dizziness, drowsiness.
Nausea, vomiting, loss of appetite, pain in the epigastric region may appear. The drug can have an ulcerogenic effect: in some cases, ulceration in the stomach and bleeding from the gastrointestinal tract can be observed.
To prevent and reduce dyspeptic phenomena, you should take the drug during or after a meal with milk, use antacid preparations. In case of allergic reactions (skin rash, etc.), antihistamines are prescribed.
The drug is contraindicated in peptic ulcer of the stomach and duodenum and other ulcerative processes in the intestine and esophagus, with bronchial asthma. You should not prescribe the drug to women during pregnancy and lactation. It is necessary to warn patients about the possibility of dizziness, especially this must be taken into account when prescribing indomethacin to drivers of vehicles, people working with machine tools, etc.