Description medications: Indomethacin (Indometacinum)

Indomethacin (Indometacinum) *. 1- (-Hlorbenzoil pair) -5-methoxy-2-methylindole-3-acetic acid.

Synonyms: Indotsid, indomethacin, Algometacin, Articin, Artrizinal, Artrocid , Bonatol, Cidalgon, Cinodocin, Cosmocalm, Dolopas, Dolovin, Elmetacin, Fortarthrin, Inacid, Indacin, Indocid, Indometacin, Indomethacin, Indomin, Indopal, Indren, Inteban, Melitex, Metacen, Mataril, Matartril, Methacid, Mathindol, Metindol, Nuricon, Peralgon, Phenotacin, Rumacid, Reumadolon, Reumatin, Sadoreum, Valicent, Vellopan and others.

Indomethacin relates to indole acetic acid derivatives. It is one of the most active non-steroidal anti-inflammatory drugs. Potent inhibitor of prostaglandin biosynthesis. It has a pronounced analgesic activity.

Indomethacin is an active anti-inflammatory agent, effective in rheumatoid arthritis, periartritah, ankylosing spondylitis, osteoarthritis, gout, inflammatory connective tissue diseases of the musculoskeletal system, thrombophlebitis and other diseases involving inflammation. It is also used in the nephrotic syndrome.

Applied indomethacin orally in the form of tablets or capsules, 0.025 g (25 mg) and tablets of prolonged action (Indomethacin retard, indomethacin ointment) containing 0,075 g (75 mg), indomethacin, and a 10% Ointment (for external application).

Take indomethacin orally after meals, usually starting with 0.025 g (25 mg) was 2 - 3 times per day (adult), then depending on the tolerability of the daily dose of 100 - 150 mg daily (in 3 - 4 divided doses).

Like other anti-inflammatory drugs, indometacin designate usually long; premature discontinuation of the drug may lead to a resumption of painful phenomena.

For treatment of acute attacks of gout designate indometacin 0.05 g 3 times a day, and for the prevention of exacerbations - 0,025 g, 2 times a day.

Indomethacin retard (retard indomethacin) receiving, from 1 tablet (75 mg), 2 times a day (morning and evening) for 5 - 10 days; followed by 1 tablet per day (in the evening). The duration of treatment depends on the effectiveness and tolerability.

When using indomethacin possible side effects: headache, dizziness, drowsiness.

May appear nausea, vomiting, loss of appetite, pain in the epigastric region. The drug may have ulcerogenic action: in some cases may occur in the stomach ulceration and bleeding from the gastro - intestinal tract.

should take the drug during or after eating, drinking milk, use Antacids drugs for the prevention and reduction of dyspeptic phenomena. In case of occurrence of allergic reactions (rash, etc.) Protivogistaminnye prescribed drugs.

The drug is contraindicated in gastric ulcer and duodenal ulcer, and other processes in the intestine and esophagus, bronchial asthma. You should not assign the drug to women during pregnancy and breastfeeding. It is necessary to warn patients of the possibility of dizziness, especially when it is necessary to consider the appointment of indometacin transport drivers, persons working at their machines, and so on. N.