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Description of the medicine: Acebutolol (Acetolol)
ACEBUTOLOL (Acetolol).
(±) -N- [3-Acetyl-4- [2-hydroxy-3 - [(1-methylethyl) amino] propoxy] phenyl] butanamide hydrochloride.
Synonyms: Acecor, Sectral, Sectral.
White or almost white powder. It is soluble in water, less in alcohol.
Cardioselective β 1 blocker. It has partial agonistic and membrane-stabilizing activity.
It is completely absorbed in the gastrointestinal tract, bioavailability is about 40%, which is associated with the effect of the "first passage" through the liver (in this case, the active metabolite diacetolol is formed); C max - 2.5 hours, T 1/2 - 12-16 hours; excreted in urine and feces mainly in the form of diacetolol.
They are mainly used for arterial hypertension, angina pectoris, supraventricular and ventricular tachyarrhythmias.
It can also be used for myocardial infarction, hypertrophic cardiomyopathy, tremor and thyrotoxicosis.
Assign inside 0.2 g 2 times a day, if necessary, increase the daily dose to 0.8-0.9 g.
The antihypertensive effect usually develops 1.5 hours after administration, reaches a maximum after 3-8 hours and lasts up to 24-30 hours.
Possible side effects, contraindications and restrictions for use are the same as for anaprilin and atenolol.
Release form: tablets of 0.2 and 0.4 g (N. 15, 20, 30).
Storage: LIST B.
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