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Medication Description: Acebutolol (Acetolol)
Acebutolol (acetolol).
(±) -N- [3-Acetyl-4- [2-hydroxy-3 - [(1-methylethyl) amino] propoxy] phenyl] butanamide hydrochloride.
Synonyms: Azekor, Sectral, Sectral.
White or almost white powder. It is soluble in water, less - in alcohol.
Cardioselective β 1 blocker. It has partial agonistic and membrane stabilizing activity.
Fully absorbed in the gastrointestinal tract, bioavailability is about 40%, which is associated with the effect of "first passage" through the liver (this produces an active metabolite, diacetolol); C max - 2.5 hours; T 1/2 - 12-16 hours; displayed with urine and feces mainly in the form of diacetolol.
Applied mainly for arterial hypertension, angina pectoris, supraventricular and ventricular tachyarrhythmias.
It can also be used for myocardial infarction, hypertrophic cardiomyopathy, tremor and thyrotoxicosis.
Assign inside of 0.2 g 2 times a day, if necessary, the daily dose is increased to 0.8-0.9 g
The antihypertensive effect usually develops 1.5 h after administration, reaches a maximum after 3-8 hours and lasts up to 24-30 hours.
Possible side effects, contraindications and restrictions to use are the same as for anaprilina and atenolol.
Product form: tablets of 0.2 and 0.4 g (N. 15, 20, 30).
Storage: LIST B.
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