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Description medications: acebutolol (Acetolol)

Acebutolol (Acetolol).

(±) -N- [3-Acetyl-4- [2-hydroxy-3 - [(1-methylethyl) amino] propoxy] phenyl] butanamide hydrochloride.

Synonyms: Atsekor, Sektral, Sectral.

White or almost white powder. It is soluble in water, it is less - in alcohol.

Cardioselective β 1 blocker. It has a partial agonisticheekoy and membrane stabilizing activity.

Completely absorbed in the digestive tract, bioavailability of about 40% due to the effect of "first pass" through the liver (with the formation of the active metabolite diatsetolol); C max - 2,5h, T 1/2 - 12-16 hours; excreted in the urine and faeces mainly as diatsetolola.

Applied mostly with hypertension, angina pectoris, supraventricular and ventricular tachyarrhythmias.

It can also be used in myocardial infarction, hypertrophic cardiomyopathy, thyrotoxicosis, and tremor.

Assign the interior of 0.2 g 2 times a day, at neobhrdimosti daily dose increased to 0.8-0.9 g

The antihypertensive effect is usually within 1.5 hours after administration, reaching a peak in 3-8 hours and lasts for up to 24-30 hours.

Possible side effects, contraindications and limitations to use are the same as those of propranolol and atenolol.

Product form: tablets of 0.2 g and 0.4 (N. 15, 20, 30).

Storage: List B.