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Description of the medicine: Somatostatin and its derivatives (Somatostatin)


Synonyms: Modustatin, Stilamin, Modustatine, Stilamin.

Hormone (tetradecapapeptide) isolated from the hypothalamus. Somatostatin secretion is also carried out by the digestive tract (especially the pancreas).

Is an inhibitor of the release of growth hormone (see), as well as prolactin, insulin, glucagon, serotonin; inhibits the formation of hydrochloric acid, pepsin, gastrin and pancreatic enzymes in the stomach; weakens the motility of the stomach and intestines; helps stop bleeding from the upper gastrointestinal tract as a result of a decrease in blood flow in the celiac arteries.

It is used for acute bleeding with peptic ulcer of the stomach and duodenum, bleeding from varicose veins of the esophagus, erosive and hemorrhagic gastritis, in the treatment of (auxiliary) pancreatic fistula, bile and intestinal fistula, to prevent complications after surgical interventions on the pancreas some types of gastrointestinal tumors (gastrinomas, carcinoids, etc.).

Assign intravenously. Doses are selected individually. Usually, 0.25 mg is administered first in a jet (within 3-5 minutes), then dropwise at a rate of 0.25 mg per hour (on an isotonic sodium chloride solution or 5% glucose solution) for 60-96 hours (48-72 h after stopping the bleeding) up to 2-20 days (until the fistula closes with fistulas).

Possible side effects: nausea, headache, abdominal pain, stool disorders, increased blood pressure, menstrual bleeding.

Sonatostatin preparations are contraindicated during pregnancy and lactation.

Release form: lyophilized powder for injection in ampoules of 2 mg (Modustatin) and 0.25 and 3 mg (Stilamin) complete with a solvent.