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Description medications: Somatostatin and its derivatives (Somatostatin)

Somatostatin and its derivatives (Somatostatin).

Synonyms: Modustatin, Stilamin, Modustatine, Stilamin.

Hormone (tetradecapeptide) isolated from hypothalamus. somatostatin secretion is carried out and the bodies of the gastrointestinal tract (especially the pancreas).

It is an inhibitor of growth hormone release (see.) As well as prolactin, insulin, glucagon, serotonin; inhibits the formation of gastric hydrochloric acid, pepsin, gastrin and pancreatic enzymes; weakens peristalsis of the stomach and intestines; It helps stop bleeding from the upper gastrointestinal tract by reducing the blood flow in the splanchnic arteries.

Applied with acute bleeding gastric ulcer and duodenal ulcers, bleeding from varices of the esophagus, erosive and hemorrhagic gastritis, the treatment of (sub) fistula of the pancreas, bile and intestinal fistula, to prevent complications after surgery on the pancreas, when some types of gastrointestinal tumors (gastrinoma, carcinoid et al.).

Assign intravenously. Doses picked individually. Usually administered first jet (within 3-5 minutes) 0.25 mg, then drip at a rate of 0.25 mg per hour (isotonic sodium chloride solution or 5% glucose solution) over a period of 60-96 hours (48-72 hours after the bleeding stops) to 2-20 days (before closing the fistula with fistula).

Possible side effects: nausea, headache, abdominal pain, stool disturbances, increased blood pressure, bleeding menstrualnopodobnye.

Sonatostatina drugs are contraindicated during pregnancy and lactation.

Product: liofinizirovanny powder for injection solutions in vials of 2 mg (Modustatin) and 0.25 and 3 mg (Stilamin) together with the solvent.