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Medication Description: Somatostatin and Its Derivatives (Somatostatin)

Somatostatin and its derivatives (Somatostatin).

Synonyms: Modustatin, Stylamin, Modustatine, Stilamin.

Hormone (tetradekapeptid), isolated from the hypothalamus. Somatostatin secretion is also carried out by the gastrointestinal tract (especially the pancreas).

It is an inhibitor of the release of somatotropin (see), as well as prolactin, insulin, glucagon, serotonin; inhibits the formation in the stomach of hydrochloric acid, pepsin, gastrin and pancreatic enzymes; weakens peristalsis of the stomach and intestines; helps to stop bleeding from the upper GI tract as a result of a decrease in blood flow in the celiac arteries.

Apply with acute bleeding in gastric ulcer and duodenal ulcer, bleeding from varicose veins of the esophagus, erosive and hemorrhagic gastritis, in the treatment of (auxiliary) pancreatic fistula, biliary and intestinal fistula, to prevent complications after surgical interventions on the pancreas, pancreatic glands. some types of gastrointestinal tumors (gastrinomas, carcinoids, etc.).

Assign intravenously. Doses are selected individually. Usually, 0.25 mg is administered initially (within 3-5 minutes), then drip at a rate of 0.25 mg per hour (in an isotonic solution of sodium chloride or 5% glucose solution) for 60-96 hours (48-72 h after stopping bleeding) up to 2-20 days (until the fistula closes with fistulas).

Possible side effects: nausea, headache, abdominal pain, abnormal stool, increased blood pressure, menstrual bleeding.

Sonatostatin preparations are contraindicated during pregnancy and breastfeeding.

Product form: lyophilized powder for injection solutions in ampoules of 2 mg (Modustatin) and 0.25 and 3 mg (Stylamine) complete with solvent.