Medication Description: Dimexide (Dimexidum)
Synonyms: DMSO, Brosorb, Damul, Deltan, Demasorb, Demavet, Dermasorb, Dimethylsulfoxid, DMSO, Dolicur, Dolocur, Dromisol, Durasorb, Hyadur, Mastan, Somipront, Syntexan, etc.
Colorless transparent liquid or colorless crystals (melting at a temperature of + 18, 5 С) with a specific smell. Hygroscopic. Mixed in all proportions with water and alcohol.
External remedy for local use in inflammatory and some other diseases (mainly in diseases of the musculoskeletal system).
The drug has the ability to penetrate biological membranes, including through skin barriers. The basis for use in inflammatory diseases of the musculoskeletal system is its analgesic and anti-inflammatory effect. The drug has a moderate antiseptic and fibrinolytic effect. It also enhances the penetration through the skin of a number of medicinal substances.
Dimexide is used both in undiluted form and in the form of solutions (10 - 30 - 50 - 70%) in double-distilled water to reduce inflammatory and pain phenomena in the complex therapy of rheumatoid arthritis, Bechterew's disease, deforming osteoarthrosis, arthropathy, as well as in bruises , sprains, traumatic infiltrates, etc. They are also used in the treatment of erythema nodosum. In combination with heparin, it is used for thrombophlebitis, in combination with antimicrobial drugs (linment synthomycin, etc.) - in the complex treatment of systemic scleroderma, furunculosis, erysipelas, acne, etc.
There is evidence of the therapeutic efficacy of Dimexide in rheumatoid arthritis and deforming osteoarthrosis, especially when combined with nonsteroidal anti-inflammatory drugs.
Apply dimexide in the form of applications. In a solution of the appropriate concentration - (usually a 50% solution, and for the skin of the face and other highly sensitive areas of the skin - 10–30% solution) wets wipes, which are applied to the affected area for 20–30 minutes 1 time a day; Wipes covered with plastic wrap, and the top - cotton or linen fabric. The course of treatment is 10 - 15 procedures daily.
Usually the drug is well tolerated, however, in some patients it may cause itchy dermatitis; some patients perceive the smell of the drug badly (nausea, retching), in rare cases, bronchiolospasm is possible.
The drug is contraindicated in violations of the antitoxic function of the liver and the excretory function of the kidneys, with angina, marked atherosclerosis, during pregnancy, glaucoma, cataracts. Due to the fact that dimexide can enhance not only the activity, but also the toxicity of some drugs, caution should be exercised when prescribing it simultaneously with other drugs.
Given the possibility of individual intolerance to the drug, it is recommended to carry out a drug test for tolerance to it.