Description of the medicine: Dimexidum (Dimexidum)
Synonyms: DMSO, Brosorb, Damul, Deltan, Demasorb, Demavet, Dermasorb, Dimethylsulfoxid, DMSO, Dolicur, Dolocur, Dromisol, Durasorb, Hyadur, Mastan, Somipront, Syntexan, etc.
Colorless transparent liquid or colorless crystals (melting at a temperature of + 18.5 ° C) with a specific odor. Hygroscopic. Miscible in all proportions with water and alcohol.
An external agent for topical application in inflammatory and some other diseases (mainly in diseases of the musculoskeletal system).
The drug has the ability to penetrate through biological membranes, including through skin barriers. The basis for use in inflammatory diseases of the musculoskeletal system is its analgesic and anti-inflammatory effect. The drug has a moderate antiseptic and fibrinolytic effect. It also enhances the penetration of a number of drugs through the skin.
Dimexide is used both in undiluted form and in the form of solutions (10 - 30 - 50 - 70%) in twice distilled water to reduce inflammation and pain in the treatment of rheumatoid arthritis, ankylosing spondylitis, deforming osteoarthritis, arthropathy, as well as bruises , sprain, traumatic infiltrates, etc. Also used in the treatment of erythema nodosum. In combination with heparin it is used for thrombophlebitis, in combination with antimicrobial agents (synthomycin liniment, etc.) - in the complex treatment of systemic scleroderma, furunculosis, erysipelas, acne, etc.
There is evidence of the therapeutic efficacy of dimexide for rheumatoid arthritis and deforming osteoarthritis, especially when combined with non-steroidal anti-inflammatory drugs.
Apply dimexide in the form of applications. In a solution of the appropriate concentration - (usually a 50% solution, and for the skin of the face and other highly sensitive areas of the skin - 10 - 30% solution), wipes are moistened, which are applied to the affected area for 20 - 30 minutes once a day; napkins are covered with plastic wrap, and on top with cotton or linen cloth. The course of treatment is 10 to 15 procedures daily.
Usually the drug is well tolerated, however, in some patients itchy dermatitis may appear; some patients have a poor perception of the smell of the drug (nausea, retching), in rare cases bronchio spasm is possible.
The drug is contraindicated in cases of impaired antitoxic function of the liver and excretory function of the kidneys, with angina pectoris, severe atherosclerosis, pregnancy, glaucoma, and cataracts. Due to the fact that dimexide can enhance not only the activity, but also the toxicity of certain drugs, caution should be exercised when it is prescribed simultaneously with other drugs.
Given the possibility of individual intolerance to the drug, it is recommended to conduct a drug test for tolerance to it.