Medication Description: Distigmine Bromide (Distigmine bromide)
Distigmine Bromide (Distigmine bromide) *. 3-Oxy-1-methyl-pyridine hexamethylene bis- (N-methylcarbamate) dibromide.
Synonyms: Ubretid, Hexfmarium bromide, Ubretid, Ubretil.
White powder, soluble in water.
It is a long-acting cholinesterase inhibitor.
Used for the prevention and treatment of postoperative intestinal atony, bladder atony, with an increase in the amount of residual urine in patients with neurogenic disorders of urination, myasthenia and other indications for the use of anticholinesterase drugs (see Prozerin, Oxazil) and holipomimetics (see Aceclidine).
Assign inside and intramuscularly. Inside give, starting with 0.5 mg (1 tablet) per day, then, depending on the effectiveness and tolerability of the drug, increase the dose to 2 tablets per day or reduce to 1 tablet 1 time in 2 to 3 days. Taken in the morning on an empty stomach (1/2 hour before breakfast).
In myasthenia, doses can be significantly increased if careful monitoring of tolerability and effectiveness is observed.
Intramuscular injection of 0.5 mg (1 ml of 0.05% solution). Repeated injections are done no earlier than 24 hours after the first injection. If necessary, long-term treatment is recommended 2 - 3-day breaks.
Possible side effects, precautions and contraindications are the same as for prozerin and other similar anticholinesterase drugs.
Method of production: tablets of 0.5 mg; 0.05% solution in 1 ml ampoules (0.5 mg).