Description of the medicine: Clomethiazole (Clometiazole)
It is chloromethiazole ethanedisulfonate, i.e. 5- (2-chloroethyl) -4-methylthiazole ethanedisulfonate.
Synonyms: Hemineurin, Hemineurin, Gemineurin, Chlomethiazole, Chlormethiazole, Clometiazole, Clomiazine, Distraneurin, Distrapax, Hemineurine, Hemineurin, Heminevrin, Somneurin, Somnevrin.
By its chemical structure, it can be considered as part of a thiamine molecule (vitamin B1), but it does not have vitamin properties, but has a sedative, hypnotic and anticonvulsant effect.
It is used for sleep disorders, epileptic status, eclampsia and preeclampsia, in conditions of acute arousal, as well as for pain relief of labor. It is an effective treatment for withdrawal symptoms in alcoholism.
Assign inside and intravenously. When taken orally in the form of capsules, it is absorbed faster and acts more actively than when taken in the form of tablets.
As a sleeping pill, 2 to 4 capsules (or tablets) are prescribed before bedtime (or in two doses), and as a sedative, 1 to 2 capsules (tablets) per day (before meals) are prescribed.
In case of epileptic status and delirium, 40-100 ml of 0.8% solution is injected intravenously for 3-5 minutes or 60-150 drops per minute after sleep, then infusion is slowed down, supporting superficial sleep. A total of 500 to 1000 ml is administered over a period of 6 to 12 hours. Then you can go on taking the drug inside.
In acute withdrawal symptoms, 2 to 4 capsules are prescribed, and if necessary, after another half hour, another 2 capsules before sedation and sleep.
Also used to alleviate withdrawal symptoms are 3 capsules per day for 2 days, then 2 capsules per day for another 3 days and 1 capsule per day for 4 days. The course lasts usually 9 days.
For pain relief, give 2-3 capsules, if necessary - another 2 - 3 capsules after 3 hours (total not more than 7 capsules).
When eclampsia is administered intravenously 30 - 50 ml of a 0.8% solution - 60 drops per minute, after drowsiness, the dose is reduced to 15 - 10 drops per minute.
In acute manic agitation, 40 to 80 ml of a 0.8% solution is administered.
Intravenous administration of hemineurin can cause local phlebitis. The drug is administered intravenously slowly. The possibility of respiratory depression, the development of hypotension and collapse should be considered. When administered, dyspeptic symptoms are possible.
In patients with alcoholism, hemineurin can cause psychological dependence. Therefore, the drug is used for no more than 6 to 7 days, it is prescribed in minimal doses giving a therapeutic effect.
Method of release: capsules containing 192 mg of chloromethiazole base in peanut butter, which corresponds to 500 mg of hemeneurin; tablets of 500 mg of hemineurin; 0.8% solution in bottles of 100 m 500 ml.