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Description of the medicine: Scopolamin (Scopolaminum)

SCOPOLAMINE (Scopolaminum).

Alkaloid, contained together with atropine in belladonna, bleached, dope, scopolia.

Applied in the form of scopolamine hydrobromide (Scorolamin hydrobromidum).

Synonyms: Scopolaminum hydrobromicum, Hyoscini hydrobromidum.

Colorless transparent crystals or white crystalline powder. Easily soluble in water (1: 3), soluble in alcohol (1:17). To stabilize solutions for injection, add a solution of hydrochloric acid to pH 2, 8 - 3, 0. Sterilize at +100 C for 30 minutes.

Chemically scopolamine is close to atropine: it is an ester of scopine and tropic acid. Close to atropine on the effect on peripheral cholinoreactive systems. Like atropine causes pupillary dilatation, paralysis of accommodation, increased heart rate, relaxation of smooth muscles, a decrease in the secretion of digestive and sweat glands.

It also has a central holinolitic effect. Usually causes a sedative effect: reduces motor activity, can have a hypnotic effect. A characteristic property of scopolamine is the amnesia caused by it.

Scopolamine is sometimes used in psychiatric practice as a sedative, in neurological practice - for the treatment of parkinsonism, in surgical practice, along with analgesics (morphine, promedol) - for preparation for anesthesia, sometimes as an antiemetic and sedative in sea and air sickness (more often for this Goals are prescribed tablets "Aeron"), as well as with irites, iridocyclitis and with a diagnostic purpose for dilatation of the pupil instead of atropine.

The contraindications are the same as when taking atropine. It is necessary to take into account a very wide difference in individual sensitivity to scopolamine: relatively often the usual doses cause not soothing, but excitement, hallucinations and other side effects.

Scopolamine is administered internally (usually in solutions and under the skin in single doses of 0.00025-0.0005 g (0.25-0.5 mg) or 0.5-1 ml of 0.05% solution. In ocular practice (for expansion Pupil and paralysis of accommodation) apply a 25% aqueous solution (1 - 2 drops in the eye 2 times a day) or 0.25% ointment

Higher doses for adults inside and under the skin: single 0.0005 g, daily 0.0015 g.

Form release: powder; 0.05% solution in ampoules of 1 ml.

In ophthalmic practice, along with 0.25% aqueous solution, a prolonged drug is used - a solution of scopolamine hydrobromide 0.25% with methylcellulose (Solutio Ssrolamini hidrobromidi 0.25% cum Methylcelluloso). Colorless transparent or slightly opalescent liquid (pH 4, 5 - 6, 5) in bottles of 5 and 10 ml.

Storage: List A. In a well-ukuporennoy container in a dark place.

RR: Sol. Scorolamini hydrobromidi 0.05% 1 ml

DtdN 6 in ampull.

DS 0.5 to 1 ml under the skin

Rp .: Scopolamini hydrocarbomidi 0.0025

Proverdoli 0.1

Еphеdrini hydrochloridi 0,125 ml

Aq. Pr for inject. 5 ml

M. Steril.!

DS Per 1 ml under the skin or intramuscularly as an anesthetic for trauma; For induction anesthesia

Rp .: Sol. Scopolamini hydrobromidi 0.25% 10 ml

DS Eye drops. 1 to 2 drops 3 to 4 times a day (with iridocyclitis)

Note: It is not allowed to take a solution of this concentration inside and insert it under the skin.

Tablets "Aeron" (Tabuleletta "Aeronom").