Description of the medicine: Platyphylline (Platyphyllinum)

PLATIFILLIN (Platyphyllinum).

The alkaloid platifillin is found in the rhizome rhomboid, or broadleaf [Senecio rhombofolius (Willd.)], Syn. Senecio platyphyllus DC, family. Compositae.

Refers to the derivatives of heliotrone (1-methyl-pyrrolizidine).

In medical practice, platifillin hydrotartrate is used (Рlatyphyllini hydrotartras).

Synonym: Platyphyllinum hydrotartaricum.

White crystalline powder of bitter taste. Easily soluble in water (1: 5 in hot, 1:10 in cold), very little - in alcohol; PH 0.2% solution 3, 6 - 4, 0. The solutions are sterilized at +100 ° C for 30 minutes.

Platifillin has holinoliticheskoe action. On the effect on peripheral cholinergic systems is close to atropine. Less active than atropine, but at appropriate doses is not inferior to the action of atropine; Better tolerated. Stronger than atropine, oppresses cholinergic systems of autonomic nervous nodules. On the central nervous system, especially on the vasomotor centers, has a calming effect. It also has antispasmodic (papaverine-like) properties.

Assign with spasms of smooth muscles of the abdominal cavity organs, peptic ulcer of the stomach and duodenum, bronchial asthma; The drug also reduces the spasms of blood vessels (with hypertension, angina pectoris), spasms of cerebral vessels.

In ophthalmic practice apply for the dilatation of the pupil. Comparatively with atropine, the influence on accommodation is little appreciable. The effect on the pupil is less prolonged than that of atropine and gomatropin (see).

For relief of acute ulcerative pains, as well as intestinal, hepatic, renal colic, platyphylline is injected under the skin with 1 -2 ml of 0.2% solution. For the course treatment (10 - 15 - 20 days) is prescribed inside (before eating) to 0,00З 0,005 g or 10 - 15 drops 0,5% solution 2 - 3 times a day or injected under the skin for 1 - 2 ml 0 , 2% solution. The drug can also be prescribed in candles for 0.01 g 2 times a day or in microclyster for 20 drops of 0.5-1% solution 2 to 3 times a day. In ophthalmic practice apply 1% solution for diagnostic purposes and 2% solution for medical purposes.

Children are prescribed 0.0002 g (0.2 mg) - 0.003 g (3 mg) per reception, depending on the age.

Higher doses for adults inside and under the skin: single 0.01 g, daily 0.03 g.

An overdose of platyphylline can cause the same phenomena as an overdose of atropine (dry mouth, palpitations, pupillary dilatation, CNS excitation, etc.).

Contraindicated in glaucoma, as well as with organic diseases of the liver and kidneys.

Form release: powder; Tablets of 0.005 g (5 mg); 0.2% solution in ampoules of 1 ml.

Storage: List A. In a well-ukuporennoy container.

Rp .: Tab. Platyphyllini hydrotartratis 0.005 N. 6

DS 1 tablet 2 to 3 times a day

Rp .: Platyphyllini hydrotartratis 0.005

Papaverini hydrochloridi 0.02

DtdN 10 in tab.

S. 1 tablet 2 to 3 times a day

Rp .: Platyphyllini hydrotartratis 0.003

Pareveini hydrochloride 0,03

Тheоbromini 0,25

DtdN 10 in tab.

S. 1 tablet 2 to 3 times a day (with angiospasm)

RR: Sol. Rlatuphullini hуdrotartratis 0,2% 1 ml

DtdN 10 in ampull.

S. Subcutaneously 1 ml 2 times a day

RR: Sol. Platurhullini hуdrotartratis 0,5% 20 ml

DS Inside 10 drops 2 times a day

RR: Sol. Platurhullini hudrotartratis 1% (2%) 10 ml

DS Eye drops (for dilating the pupil)

Tablets "Tepafillin" (Tabolletae "Therarhullinum").