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Description of the medicine: Platyphyllin (Platyphyllinum)

PLATIFILLIN (Platyphyllinum).

The alkaloid platyphyllin is found in the rhomboid or broadleaf cross [Senecio rhombofolius (Willd.)], Syn. Senecio platyphyllus DC, fam. Compositae (Compositae).

Refers to heliotridane derivatives (1-methyl-pyrrolisidine).

In medical practice, platifillin hydrotartrate (Platyphyllini hydrotartras) is used.

Synonym: Platyphyllinum hydrotartaricum.

White crystalline powder of bitter taste. Easily soluble in water (1: 5 in hot, 1:10 in cold), very little in alcohol; pH of a 0.2% solution of 3, 6 - 4, 0. The solutions are sterilized at +100 ° C for 30 minutes.

Platifillin has a cholinolytic effect. By its effect on peripheral cholinergic systems it is close to atropine. Less active than atropine, but at appropriate doses, not inferior to atropine in action; better tolerated. Stronger than atropine, inhibits cholinergic systems of autonomic nerve nodes. On the central nervous system, especially on the vasomotor centers, has a calming effect. It also has antispasmodic (papaverin-like) properties.

Assign with spasms of smooth muscles of the abdominal cavity, peptic ulcer of the stomach and duodenum, bronchial asthma; the drug also reduces blood vessel spasms (with hypertension, angina pectoris), cerebral vasospasms.

In ophthalmic practice, they are used to dilate the pupil. Compared with atropine, the effect on accommodation is not noticeable. The effect on the pupil is shorter than the effect of atropine and homatropin (see).

To stop acute ulcerative pain, as well as intestinal, hepatic, and renal colic, platifillin is administered under the skin in 1-2 ml of a 0.2% solution. For a course of treatment (10 - 15 - 20 days), 0.005 g or 0.003 g or 10-15 drops of a 0.5% solution are prescribed orally (before meals) 2 to 3 times a day or 1 to 2 ml is administered under the skin 0 , 2% solution. The drug can also be prescribed in suppositories of 0.01 g 2 times a day or in microclysters of 20 drops of 0.5 - 1% solution 2 - 3 times a day. In eye practice, a 1% solution for diagnostic purposes and a 2% solution for medical purposes are used.

Children are prescribed 0.0002 g (0.2 mg) - 0.003 g (3 mg) per dose, depending on age.

Higher doses for adults inside and under the skin: single 0.01 g daily 0.03 g

An overdose of platyphyllin can cause the same phenomena as an overdose of atropine (dry mouth, palpitations, dilated pupils, central nervous system excitation, etc.).

Contraindicated in glaucoma, as well as in organic diseases of the liver and kidneys.

Method of release: powder; tablets of 0.005 g (5 mg); 0.2% solution in ampoules of 1 ml.

Storage: List A. In well-closed containers.

Rp .: Tab. Platyphyllini hydrotartratis 0.005 N. 6

DS 1 tablet 2 to 3 times a day

Rp .: Platyphyllini hydrotartratis 0.005

Papaverini hydrochloridi 0.02

DtdN 10 in tab.

S. 1 tablet 2 to 3 times a day

Rp .: Platyphyllini hydrotartratis 0.003

Paraverini hydrochloridi 0.03

Thebromini 0.25

DtdN 10 in tab.

S. 1 tablet 2 to 3 times a day (with angiospasm)

Rp.: Sol. Platuphúllini hódrotartratis 0.2% 1 ml

DtdN 10 in ampull.

S. Subcutaneously 1 ml 2 times a day

Rp.: Sol. Platurhullini houdrotartratis 0.5% 20 ml

DS Inside 10 drops 2 times a day

Rp .: Sol. Platurhullini houdrotartratis 1% (2%) 10 ml

DS Eye drops (for dilating the pupil)

Tablets "Tepafillin" (Tambletae "Therarhullinum").