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Description of the medicine: Spasmolytinum (Spasmolytinum)

SPASMOLITIN (Spasmolytinum). ~ 1,1-Diphenylacetic acid diethylaminoethyl ester hydrochloride.

Synonyms: Difacil, Adiphenin, Trasentin, Vagospasmyl, Veganthin.

White crystalline powder of a salty-bitter taste. Easily soluble in water. When dry, it is resistant, aqueous solutions are gradually hydrolyzed,

It has peripheral m-anticholinergic activity; in addition, it has a blocking effect on n-cholinergic systems. It has antispasmodic activity: relaxes the smooth muscles of internal organs and blood vessels; also causes local anesthesia.

It is used for pylorospasm, spastic colic, gallstone disease, renal colic, gastric ulcer and duodenal ulcer, with angina pectoris, endarteritis, as well as neuralgia, neuritis, radiculitis. There is evidence of the effectiveness of the drug for itchy dermatoses, as well as for migraines.

Prescribe spazmolitin inside after eating 0.05 - 0.1 g 2 - 3 - 4 times a day. The course of treatment is 3 to 4 weeks.

When using antispasmodic (as well as other anticholinergics), the dose should be individually selected. In case of an overdose, dizziness, headache, a feeling of intoxication (due to the central effect), dry mouth (due to the peripheral cholinolytic effect), and disturbance of accommodation may appear.

Having an irritating effect on the gastric mucosa, spasmolitin can cause dyspeptic symptoms.

The feeling of intoxication and dizziness can be prevented or weakened by the appointment of caffeine (0.1 - 0.2 g of sodium caffeine-benzoate inside or 1 ml of a 20% solution under the skin).

Spazmolitin and drugs close to it (arpenal, etc.) should not be taken before and during work, transport drivers and other persons whose profession requires a quick mental and physical reaction.

Contraindicated in glaucoma.

Release form: powder.

Storage: List B. In a dry, dark place.

Abroad under the name "Neuro-Trasentin" tablets are produced containing 0.03 g of trazentin (antispasmodic) and 0.04 g of phenobarbital. It is used as a sedative and anticholinergic drug (for neurosis, increased irritability, functional disorders of the gastrointestinal tract).