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Medication Description: Spasmolitin (Spasmolytinum)

SPASMOLITIN (Spasmolytinum). ~ 1-1-diphenylacetic acid diethylaminoethyl ester hydrochloride.

Synonyms: Difacil, Adiphenin, Trasentin, Vagospasmyl, Veganthin.

The white crystalline powder is a saltish bitter taste. Easily soluble in water. Dry racks, aqueous solutions gradually hydrolyze,

Possesses peripheral m-cholinolytic activity; In addition, it has a blocking effect on n-cholinergic systems. It has spasmolytic activity: relaxes smooth muscles of internal organs and blood vessels; also causes local anesthesia.

Applied with pylorospasm, spastic colic, gallstone disease, renal colic, gastric ulcer and duodenal ulcer, with angina, endarteritis, as well as with neuralgia, neuritis, radiculitis. There is evidence of the effectiveness of the drug in itchy dermatosis, as well as migraine.

Assign spasmolitin inside after eating at 0.05 - 0.1 g 2 - 3 - 4 times a day. The course of treatment for 3 - 4 weeks.

When using spasmolitin (as well as other anticholinergics) should be individually adjusted dose. In case of overdose, dizziness, headache, feeling of intoxication (due to central action), dry mouth (due to peripheral cholinolytic action), accommodation disturbance may appear.

Having an irritating effect on the mucous membrane of the stomach, spasmolitin can cause dyspeptic symptoms.

The feeling of intoxication and dizziness can be prevented or weakened by the appointment of caffeine (0.1 - 0.2 g of caffeine sodium benzoate orally or 1 ml of a 20% solution under the skin).

Antispasmodic and drugs close to it (arpenal, etc.) should not be taken before and during work by drivers of transport and other persons whose profession requires a quick mental and physical reaction.

Contraindicated in glaucoma.

Form release: powder.

Storage: List B. In a dry, dark place.

Abroad, under the name "Neuro-Trasentin" tablets containing 0.03 g of trazentin (spasmolitin) and 0.04 g of phenobarbital are produced. Used as a sedative and anticholinergic (with neurosis, increased excitability, functional disorders of the gastrointestinal tract).