Description of the medicine: Metacin (Methacinum)
METACIN (Methacinum). Benzylic acid 2-dimethylaminoethyl ester iodomethylate.
Synonym: Metacinum iodide.
White or white, with a slightly yellowish tinge, crystalline powder. It is soluble in water (1: 200). Aqueous solutions (pH 4, 0-5, 0) are sterilized at + 100 ° C for 30 minutes.
Metacin is a very active m-anticholinergic drug. Being a quaternary ammonium compound, it poorly penetrates the blood-brain barrier and is therefore a selectively acting peripheral anticholinergic.
Metacin acts more strongly on peripheral cholinergic receptors than atropine and antispasmodic. By its effect on bronchial muscles, it is more active than atropine. Strongly inhibits the secretion of salivary and bronchial glands. Relaxes the smooth muscles of the esophagus, stomach, intestines. At the same time, it has a significantly lesser mydriatic effect than atropine, which, apparently, is due to the fact that it is difficult to penetrate the blood-brain barrier.
Metacin is used as an anticholinergic and antispasmodic agent for diseases accompanied by spasms of smooth muscle organs.
Metacin is very effective for gastric ulcer and chronic gastritis. It eliminates motor dysfunction of the stomach and duodenum, normalizes motility; superior to atropine in analgesic effect.
Metacin can be used in the treatment of patients with peptic ulcer in combination with other drugs.
Metacin is a very effective drug for the relief of renal and hepatic colic.
In anesthetic practice, they are used to reduce salivation and secretion of the bronchial glands, as well as to reduce bronchial spasm and circulatory disorders that may occur as a result of anesthesia and irritation of the branches of the vagus nerve. Compared with atropine, metacin is more convenient for use, since, having a lesser mydriatic effect, it makes it possible to monitor changes in the diameter of the pupil during the operation. For premedication, metacin is also preferable because the heart rate is less pronounced, and in bronchodilator action it is significantly superior to atropine.
Metacin can be used to relieve increased excitability of the uterus with the threat of premature birth and late miscarriages, for sedation during cesarean section operations. The use of the drug reduces the amplitude, duration and frequency of contractions of the uterus.
Metacin is an effective means to lower the tone and decrease the motor activity of the esophagus, stomach and duodenum during their X-ray examination.
Metacin is administered orally and parenterally (under the skin, in the muscles and in the vein). Inside, methacin is prescribed (before meals) at 0.002-0.005 g (2-5 mg) 2-3 times a day. The course of treatment usually lasts 2 to 4 weeks. Under the skin, in the muscles and vein, 0.5 to 2 ml of a 0.1% solution is injected.