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Description of the medicine: Pachycarpinum

PAHICARPIN (Pachycarpinum).

Pahikarpin - an alkaloid, contained in the plant is a copepod fossil (Sorhora rahycarpa SAAM), family. Beans (Leguminosae); It is also found in Thhermopsis lanceolata R. Br. And other plants.

In medical practice, pakhycarpine hydroiodide (Rachicarpini hydroiodidum) is used.

Synonyms: d-Spartein hydroiodide, Pachycarpinum hydroiodicum.

White crystalline powder of bitter taste. Soluble in water (1:30), solutions for injections are sterilized at a temperature of +100 ° C for 30 minutes; PH 3% solution 6, 7 - 7, 6.

Pachycarpine is a two-tertiary base: unlike benzohexonium and similar preparations, pachycarpin does not contain quaternary nitrogen atoms ("onium groups"); However, pachycarpine, like these compounds, has the ability to block vegetative ganglia. Pachycarpine is less active in this respect, however it is convenient for oral administration, since it is easily absorbed from the gastrointestinal tract.

Apply pahikarpin as ganglioblokatora mainly with spasms of peripheral vessels, as well as ganglionitis. Pachycarpine improves muscle function in myopathy.

Assign inside (before meals), subcutaneously and intramuscularly. With obliterating endarteritis, give inside 0.05-0.1 g 2-3 times a day. Treatment is carried out for 3 to 6 weeks. After 2 - 3 months, the course of treatment with exacerbation of the process can be repeated. With ganglionitis, appoint inward to 0,05 - 0,1 g 2 times a day for 10 to 15 days. With myopathy appoint inward to 0.1 g 2 times a day for 40 - 50 days. The course of treatment is repeated 2 - 3 times after 1 2 - 3 months.

One of the important features of pachycarpine is its ability to tone up and strengthen the contraction of the uterus musculature. In connection with this, pachycarpin was relatively widely used to enhance labor activity in cases of weakness in labor and in early water withdrawal, as well as in weakness of attempts. The drug, in contrast to pituitrin does not cause an increase in blood pressure and can be administered to women who suffer from hypertension.

Forms of release: tablets of 0.1 g; 3% solution in ampoules of 2 ml.

Storage: List B. In the dark place.

In recent years, in connection with the emergence of more effective drugs pachycarpine for these purposes are used relatively rarely.

If pachycarpine is used to stimulate labor, it is prescribed intramuscularly or subcutaneously with 2-4 ml of a 3% solution (less often by 0.1-1.15 g per reception); After 1 to 2 hours the drug can be re-introduced. The stimulating effect begins to appear after 5 to 30 minutes after the administration of pachycarpine. For greater efficiency, it is possible to simultaneously administer quinine inside at 0.2 g every 30 minutes (4 times in total). With subinvolution of the uterus in the puerperium give pachycarpin inward by 0.1 g 2 - 3 times a day.

Higher doses for adults inside: single 0.2 g, daily 0.6 g; Under the skin: a single 0.15 g (5 ml of a 3% solution), a daily 0.45 g (15 ml of a 3% solution).