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Description medications: Kvalidil (Qualidilum)

KVALIDIL (Qualidilum). 1, 6-hexamethylene bis- (3 benzilhinuklidiny chloride) tetrahydrate.

The white crystalline powder. The easily soluble in water and alcohol; aqueous solutions of pH 5, 5 - 7 5.

Antidepolyarizuyuschego muscle relaxant. Used for muscle relaxation and controlled breathing under anesthesia, can be applied for tracheal intubation.

Enter kvalidil intravenously. At a dose of 1 mg / kg of the drug causes muscle relaxation, continuing for about 10 minutes, with some respiratory depression. Doses of 1, 2 - 1, 5 mg / kg causes muscle relaxation, prodolzhayuaschuyusya 15 - 20 min, with some patients apnea occurs for 4 - 5 minutes. Typically, the dose used in cases where tracheal intubation is performed using ditilin. Full muscle relaxation occurs at the dose of 1, 8 - 2 mg / kg, while apnea continues on average 17 - 25 min. At a dose of 2 mg / kg muscles begin to relax through 1/2 - 2 minutes and complete apnea and muscle relaxation occur after 1, 5 - 4 min.

Exit status kurarizatsii occurs gradually, after the onset of spontaneous breathing muscle relaxation is maintained for 15 - 20 minutes; 25 - Points min muscle tone and breathing normally fully restored.

For the first administration kvalidil applied at the rate of 1, 5 - 2 mg / kg.

If necessary to extend its action kvalidila administered repeatedly, reducing subsequent doses of 1, 5 - 2 times.

The total duration of operation 1, 5 - 2 hours spent 200 - 220 mg.

Neostigmine is an antagonist kvalidila.

Kvalidil not alter blood pressure but causes a moderate tachycardia. A number of patients have increased salivation and sweating; to reduce salivation intravenously administered atropine (0.2 - 0.3 ml of 0.1% solution). Some patients may receive dermahemia front of the neck and upper body, passing within a few minutes.

Contraindications and precautions are the same as for diplatsina. Like other muscle relaxants kvalidil only indotrahealnom used in anesthesia and under the conditions required for ventilation. Due to the possibility of tachycardia should use caution in patients with cardiovascular disorders.

Broad application kvalidil not.

Product: 2% solution in ampoules of 1; 2 and 5 ml of a package of 10 vials.

Storage: List A. In the dark spot.