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Description medications: Melliktin (Mellictinum)

MELLIKTIN (Mellictinum).

Melliktinom called hydroiodide metillikakonitina alkaloid contained in plants setchatoplodnaya larkspur (Delphinium dictiocarpum), larkspur poluborodataya (Delphinium semibarbatum) et al., The buttercup family (Ranunculaceae).

On chemical structure of the aconitic alkaloids. It is a tertiary base composition C 37 H 50 O 10 N 2. White or white with a slight yellowish or pink shade crystalline powder. Slightly soluble in water and alcohol. In the light turns yellow.

Melliktin has kurarepodobnymi properties. According to the mechanism of action on neuromuscular conductivity close to d-tubocurarine.

Unlike d-tubocurarine, diplatsina and other similar drugs melliktin molecule does not contain quaternary nitrogen atoms, it is absorbed in the stomach upon administration and has in this way of administration, as well as for parenteral administration, neuromuscular blocking effect on conductivity. Melliktina antagonists are Neostigmine and other anticholinesterase agents (galantamine).

The drug also has a moderate ganglion-blocking action.

Apply for reducing muscle tone with pyramidal insufficiency and vascular inflammatory origin, postentsefaliticheskom parkinsonism and Parkinson's disease, Little, arahnoentsefalite and spinal arachnoiditis and other diseases of the pyramidal and extrapyramidal nature, accompanied by an increase in muscle tone and motor function disorders.

Assign inside of 0.02 g, starting at 1 times and bringing up to 5 times a day. The course of treatment from 3 weeks to 2 months. After 3 - 4-month break, repeat the treatment. melliktinom Treatment combined with testimony from other treatments and physiotherapy.

The drug is contraindicated in myasthenia gravis and other diseases accompanied by a decrease in muscle tone with abnormal liver and kidney function, as well as in cardiac decompensation.

With the correct dosage melliktin tolerated without side effects. In cases of hypersensitivity to the drug or overdose and the development of feelings of weakness or signs of respiratory depression should be performed artificial respiration, oxygen and appoint enter slowly into a vein 0.5 - 1 ml of 0.05% solution of neostigmine with atropine (0.5 - 1 ml of 0.1% solution). Treatment should be under close medical supervision.

Product: tablets of 0.02 g (20 mg).

Storage: List A. In the dark spot.