Description medications: Mezaton (Mesatonum)
Mezaton (Mesatonum). 1- (m-hydroxyphenyl) -2-methylaminoethanol hydrochloride.
Synonyms: Adrianol, Almefrin, Derizene, Idrianol , Isophrin, Neophryn, Neo-Synephrine, Phenylephrini hydrochloridum, Phenylephrine hydrochloride, m-Sympatol, Visadron and others.
White or white with a slightly yellowish white crystalline powder and odorless. The easily soluble in water and alcohol. The solutions (pH 3 0 - 3 5) sterilized at 100 "C for 30 min.
Mezaton- Adrenomimeticalkie synthetic drug. It is a stimulant adrenoceptor; b little effect on the receptors of the heart. Causes arteriolar narrowing and high blood davlsniya (with a possible reflex bradycardia). As compared with noradrenaline and adrenaline increases blood pressure less strongly, but operates more durable. Cardiac output was influenced mezatona not increased (may even decrease).
The drug causes mydriasis and can lower intraocular pressure in open angle glaucoma forms.
Unlike adrenaline and noradrenaline is not mezaton catecholamine (it contains only one hydroxyl group in aromatic nucleus) and little exposed to the enzyme catechol-O-methyltransferase (COMT) involved in the biotransformation of catecholamines. Therefore mezaton more stable, it has a more long-lasting effect; effective when administered (but less than when administered parenterally).
Apply mezaton to increase blood pressure in the collapse and hypotension associated with a decrease in vascular tone (but not in primary heart failure), in preparation for operations and during operations, with intoxication, infectious diseases, hypotension; for narrowing vessels and reducing inflammation with vasomotor and hay fever, conjunctivitis and so on. etc .; as a substitute for epinephrine in the anesthetic solution; to expand the pupil.
In acute mezaton lowering blood pressure in a vein is typically administered at a dose of 0.1 - 0.3 - 0.5 mL of 1% solution in 40 ml 5 - 20 - 40% glucose solution and isotonic sodium chloride solution; administered slowly, repeated injections if necessary. Drip administered 1 ml of a 1% solution in 250 - 500 ml of 5% glucose solution.
Subcutaneously or intramuscularly administered 0.3 - 1 ml of a 1% solution (adults) inside - 0.01 - 0.025 g 2-3 times a day.
To narrow the blood vessels of the mucous membranes and reduce inflammation applied by smearing or instillation of 0.25 - 0.5% solutions. For local anesthesia is added 0.3 - 0.5 mL of 1% solution of 10 ml anesthetic substance.
To expand the pupil is introduced into the conjunctival sac 2 - 3 drops of 1 - 2% solution mezatona. Mydriatic effect is less extensive than in the application of atropine (several hours).
Mezaton as other sympathomimetic causes pupil dilation without affecting accommodation.
Higher doses for adults inside: single 0.03 grams daily 0.15 g; subcutaneously and intramuscularly: single 0.01 g, 0.05 g daily; In vein: single 0,005 grams daily 0,025 g
Contraindicated in hypertension, atherosclerosis, tendency to spasm of blood vessels.