Description of the medicine: Orciprenaline sulfate (Orciprenalini sulfas)

ORCIPRENALINA SULFAT (Orciprenalini sulfas) *. 1- (3, 5-Dioxyphenyl) -2- (isopropylamino) ethanol-1 sulfate.

Synonyms: Alupent, Astomopent, Alotec, Alupent, Astor, Dosalupent, Metaproterenolsulfat, Novasmasol, Orciprenaline sulfate.

The chemical structure and pharmacological properties are close to the isadrin (the base of orciprenaline differs from the isadrin by the arrangement of the hydroxyl groups at the benzene core).

The drug is a stimulant of b-adrenoreceptors of mixed type, acts on b 1 - and b 2 -adrenoceptors, but in comparison with izadrin acts more selectively for b 2 -adrenoceptors of the bronchi than the heart, to a lesser degree causes tachycardia and lowering of blood pressure. Has a longer bronchodilator effect than isazrin. After inhalation of orciprenaline (alupent, asthmopent), the effect occurs in 10-15 minutes, reaches a maximum after 1 hour and lasts up to 4-5 hours.

The main indications for use are the same as for isadrin: bronchial asthma, chronic asthmatic bronchitis, pneumosclerosis, emphysema, and atrioventricular conduction disorders.

Apply orciprenaline in the form of inhalations and parenteral.

To stop and prevent attacks of bronchial asthma use a special aerosol inhaler, when pressed on the valve which is sprayed with a constant dose of the drug, equal to 0.75 mg. One inhalation is usually enough; If necessary, make a second inhalation after 5 minutes. Before pressing the valve, the inhaler is turned upside down.

For relief of asthma attacks, the drug may also be administered intramuscularly or subcutaneously: adults 0.5-1 mg (1-2 ml 0.05% solution), sometimes intravenously: 1 ml 0.05% solution (0.5 mg ) Is administered slowly (within 3 minutes).

With long-term therapy, to prevent attacks of bronchial asthma appoint orciprenaline in the form of tablets (0.02 grams per tablet): adults 1/2 to 1 tablet 3 to 4 times a day; Children - 1/4 -1/2 tablets 2 4 times a day. The effect of ingestion occurs usually after 1 hour and lasts 4 to 6 hours.

With atrioventricular blockade, use the drug with caution, injecting slowly intravenously 0.5-1 ml of 0.05% solution, either intramuscularly or subcutaneously 1 to 2 ml; If necessary, administer the drug by slow intravenous infusion.

For infusion, dilute the contents of 1-2 ampoules of 10 ml of a 0.05% solution (5-10 mg total) in 250 ml of a 5% solution of glucose or an isotonic sodium chloride solution and inject at a rate of 10-20 drops per minute.

To prevent attacks in the Adams-Stokes-Morgagni syndrome, with absolute bradyarrhythmia and intoxication with drugs, digitalis is prescribed by mouth 1/2 to 1 tablet (adult) 6-10 times a day, changing the dose and frequency of receptions depending on the rhythm of the heart.

Orciprenaline is usually better tolerated than isadrine, but with its use, side effects are possible, the same as with the application of isadrin (see). With intravenous administration, it is possible to lower blood pressure.