Description of the medicine: Dihydroergotoxin (Dihydroergotoxinum)
The dihydrogenated derivative of the sum of alkaloids of the ergotoxin group (ergocristine, ergocornin, ergocriptine), similar in structure and pharmacological properties to dihydroergotamine.
Available in the form of methanesulfonate (mesylate).
Synonyms: Redergin, Secatoxin, Ergotoxin DG, Alkergot, Circanol, Clavor, DH-Ergotoxin, Erginemin, Ergocomb, Ergodibat, Ergohydrin, Ergoloid mesylat, Ergomed, Ergoxyl, Hyderan, Hydergin, Optamine, Redergin, Rederotin, Secot, Secamin, Vasolax et al.
For medical use, it is available in the form of tablets and solutions.
Redergin tablets (Tabulettae "Redergini" 0.0015) contain 0.0015 g (1.5 mg) of dihydroergotoxin methanesulfonate (synonym: Ergoloid mesylate, Ergoloid mesylate).
Assign to adults as a vasodilator in cases of cerebrovascular accident, migraine, consequences of traumatic brain injury, as well as peripheral circulation disorders: Buerger’s disease, Raynaud’s disease, transient arterial hypertension, circulatory disorders in the retina, and with cochleovestibular syndrome, etc. .
Take 1 tablet 3 times a day before meals. Usually taken for a long time: from 3 to 4 weeks to several months, depending on the severity of the disease, effectiveness, tolerance.
Abroad, dihydroergotoxin methanesulfonate (DH-Ergotoxin) * is also available in the form of drops for oral administration and solutions for parenteral use.
With hypertension and peripheral circulation disorders, start with the appointment of 5 drops of the drug orally 3 times a day, then increase the dose daily by 2 to 3 drops per dose to 20 to 40 drops 3 times a day. The course of treatment for hypertension lasts 3 to 4 months; with spasms of peripheral vessels - 15 to 20 days. In case of spastic migraine, 5 drops are prescribed 3 times a day in the first days, then the dose is increased to 20 - 25 drops 3 times a day.
In severe peripheral circulation disorders, they are administered intramuscularly, under the skin or intravenously (drip), 1 to 2 ml of an injection solution (1 to 2 ampoules of 0.3 mg each).
With endarteritis, sometimes 1 to 2 ampoules (0.3 0.6 mg) are administered intraarterially. Also introduced by electrophoresis (from the positive pole), 1 - 2 ampoules (0.3 - 0.6 mg) per day.
Method of release: in ampoules of 1 ml (0.3 mg) in a package of 50 ampoules; in 50 ml vials (1 mg in 1 ml).
Storage: List B. In the dark place at a temperature of no higher than + 25 'C.