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Description medications: Phentolamine (Phentolaminum)

Phentolamine (Phentolaminum). 2- [N-p-tolyl-N- (m-hydroxyphenyl) - aminomethyl] -imidazolina hydrochloride.

Synonyms: Regitin, Dibasin, Phentolamine, Regitine, Rogitine .

Produced in the form of phentolamine hydrochloride (Rhentolamini hydrochloridum).

White or slightly off-white crystalline powder. Slightly soluble in water, it is difficult - in alcohol.

Phentolamine is a synthetic compound, one of the main representatives of a modern adrenoblokatorov. The drug has a adrenoblokiruyuschee indiscriminate effects, affecting both the postsynaptic a 1 - and presynaptic a 2 adrenergic receptors.

The basis for the use of phentolamine as well as other a adrenoblokatorov as a drug blocking effect on the transmission of pulses adrenergic vasoconstrictor, which leads to the removal of spasms and expansion of peripheral blood vessels, and particularly arteriolar precapillaries, improve blood supply to the muscles, skin, mucous membranes ; there is also lowering blood pressure.

Applies phentolamine in disorders of peripheral circulation (Raynaud's disease, endarteritis, akrotsianoz, the initial stages of atherosclerotic gangrene), in the treatment of venous ulcers of the extremities, weak healing wounds, bedsores, frostbite, and in pheochromocytoma.

There are indications that a phentolamine and other adrenoblokatory (pirroksan) increase the secretion of insulin, so that they can be useful in patients with diabetes with increased secretion of adrenaline.

Assign phentolamine hydrochloride orally in the form of tablets: adults to 0.05 g, 0.025 g for children 3 - 4 times a day (after eating); In more severe cases, the dose was increased to 0.1 g (adults) 3 - 5 times per day. The course of treatment lasts 3 - 4 weeks.

When applying phentolamine, as well as a adrenoblokatorov other, it should be noted that overdosing can lead to the development of orthostatic collapse.

Due to the indiscriminate effect, with a 2-adrenoceptor blockade in the application of phentolamine is observed tachycardia, and possible dizziness, redness and itching of the skin, swelling of the nasal mucosa, and sometimes nausea and vomiting, and diarrhea. These phenomena are in dose reduction or interruption of treatment.

The drug is contraindicated in organic abrupt change of heart and blood vessels.

Form release phentolamine hydrochloride: powder and pills to 0,025 g (25 mg).

Storage: List B. In the dark spot.

Rp .: Tab. Phentolamini hydrochloridi 0,025 N. 30

DS 1 tablet 3 times a day (after eating)
3 and overseas phentolamine (methanesulfonate) is also available in vials for injection. Injection preperat used in hypertensive crises, violations of peripheral blood.