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Medication Description: Ethosuximide (Ethosuximidum)

ETUSOKSIMID (Ethosuximidum). 3-Ethyl-3-methylpyrrolidin-2, 5-dione, or a-ethyl-a-methylsuccinimide.

Synonyms: Asamid, Pyknolepsin, Ronton, Suksilep, Etomal, Aethosuximid, Asamid, Ethymal, Etomal, Pemalim, Petinimid, Pyknolepsin, Ronton, Succimal, Suxilep, Zarontin, etc.

It has anticonvulsant activity, which is manifested, as in trimetin, with small forms of epilepsy. Effective also in myoclonic attacks. Somewhat less toxic than trimethine.

Assign inside (taken with meals). The initial daily dose for children is 0.25 g, for older children and adults - 0.25 - 0.5 g per day with a gradual increase in the dose for adults to 0.75 - 1 g per day (in 3 - 4 doses).

The drug has an analgesic effect in trigeminal neuralgia (see Carbamazepine), but is somewhat less effective than carbamazepine. Assign a dose of 0.25 g, gradually increasing the dose to 0.5 - 1 g per day. Maintenance dose of 0.25 g per day.

Possible side effects: gastrointestinal disorders, in rare cases - headache, dizziness, skin rash, photophobia. Parkinsonism may occur. The possibility of neutropenia, agranulocytosis, albuminuria is not excluded.

In the course of treatment it is necessary to make blood and urine tests.

It should be borne in mind that the drug can provoke the occurrence of large epileptic seizures.

Ethosuximide penetrates the placental barrier into the milk of lactating women. Therefore, pregnant and lactating is not recommended to prescribe the drug.

Method of production: under the name "Suksilep" is available in capsules of 0.25 g (in a package of 100 and 150 pieces) and in the form of a solution containing in 100 ml of 5 g of the preparation, 25 g of glycerin and 25 ml of water-alcohol mixture (in bottles of 50 g); 15 drops of the solution contain 0.25 g of ethosuximide.

Storage: List B.