Description of the medicine: Ethosuximid (Ethosuximidum)
ETHOSUKSIMID (Ethosuximidum). 3-Ethyl-3-methylpyrrolidin-2, 5-dione, or a-ethyl-a-methylsuccinimide.
Synonyms: Asamide, Piknolepsin, Ronton, Suksilep, Etomal, Aethosuximid, Asamid, Ethymal, Etomal, Pemalim, Petinimid, Pyknolepsin, Ronton, Succimal, Suxilep, Zarontin, etc.
It has anticonvulsant activity, which manifests itself, as in trimethine, in small forms of epilepsy. It is also effective in myoclonic seizures. Somewhat less toxic than trimethine.
Assign inside (taken with food). The initial daily dose for children is 0.25 g, for older children and adults - 0.25 - 0.5 g per day with a gradual increase in the dose for adults to 0.75 - 1 g per day (in 3 to 4 doses).
The drug has an analgesic effect in trigeminal neuralgia (see carbamazepine), but is slightly less effective than carbamazepine. Assign a dose of 0.25 g, gradually increasing the dose to 0.5 - 1 g per day. Maintenance dose of 0.25 g per day.
Possible side effects: gastrointestinal upset, in rare cases, headache, dizziness, skin rash, photophobia. Parkinsonism phenomena may occur. The possibility of the appearance of neutropenia, agranulocytosis, albuminuria is not excluded.
During treatment, blood and urine tests must be performed.
It should be borne in mind that the drug can provoke the appearance of large attacks of epilepsy.
Ethosuximide crosses the placental barrier into the milk of lactating women. Therefore, it is not recommended to prescribe a drug for pregnant and lactating women.
Method of release: under the name "Suksilep" is available in capsules of 0.25 g (in packs of 100 and 150 pieces) and in the form of a solution containing 5 ml of the drug in 100 ml, 25 g of glycerol and 25 ml of a water-alcohol mixture (in 50 g vials); 15 drops of the solution contain 0.25 g of ethosuximide.
Storage: List B.