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Description of the drug: Metoprolol (Metoprolol)

METOPROLOL.
(#) - 1- (Isopropylamino) -3- [p- (methoxyethyl) phenoxy] -2-propanol.

Synonyms: Betaloc, Bloxane, Spexicor, Beloc, Betaloc, Blocksan, Lopressor, Veobloc, Opresol, Selopral, Specior and others.

Produced in the form of bitartrate.

It is selective (cardioselective) b 1 -adrenoceptor. Inner sympathomimetic activity does not possess.

By action is close to atenolol (see).

When ingested quickly absorbed. The half-life period from blood plasma is 3 to 5 hours, but the effect on blood pressure and heart rate is observed (after ingestion of 100 mg once) for 12 hours. It is excreted through the kidneys in the form of metabolites.

Applied with hypertension, angina, arrhythmias (supraventricular tachycardia, atrial fibrillation, ventricular extrasystole), with hyperthyroidism, for the prevention of repeated myocardial infarctions.

Apply inside and intravenously.

Inside appoint a dose of 100 - 200 mg per day in 2 - 3 doses. If necessary, the dose is increased, and in case of hypertension, in the case of insufficient effectiveness, other antihypertensives are prescribed additionally.

Intravenous (for urgent indications) is administered, starting with 5 mg (at a rate of 1 - 2 mg per minute); If necessary, injected repeatedly at intervals of 5 minutes to a total dose of 10 to 15 mg. Supportive therapy is administered by administering the drug inside at a dose of 200 mg per day.

Possible side effects, precautions and contraindications are the same as those of other b-adrenoblockers. Intravenously, metoprolol should not be administered if the systolic blood pressure is less than 110 mm Hg. Art. In patients with bronchospastic phenomena, simultaneous administration of b - adrenostimulating drugs is recommended.

Forms of release: tablets of 50 and 100 mg in a package of 30; 100 and 200 pieces; 1% solution in ampoules of 5 ml in a package of 10 ampoules. Storage: List B. At a temperature not higher than + 25 ° C.