Description of the medicine: Diphenhydramine (Dimedrolum)
DIMEDROL (Dimedrolum). b-Dimethylaminoethyl ester of benzhydrol hydrochloride.
Synonyms: Alledryl, Allergan, Allergival, Amidryl, Benadryl, Benzhydraminum, Diabenyl, Dimedryl, Dimidril, Diphenhydramine, Diphenhydramini hydrochloridum, Diphenhydramine hydrochloride, Restamin, etc.
White crystalline powder of bitter taste; causes numbness of the tongue. Hygroscopic. Easily soluble in water, very easily in alcohol. Aqueous solutions (pH 1% solution 5, 0 - 6, 5) are sterilized at +100 ° C for 30 minutes.
Diphenhydramine is one of the main representatives of the group of antihistamines that block H 1 receptors. It has a very pronounced antihistamine activity. In addition, it has a local anesthetic effect, relaxes smooth muscles as a result of direct antispasmodic action, it blocks to a moderate degree cholinergic receptors of autonomic nerve nodes.
Diphenhydramine is well absorbed when taken orally. Penetrates through the blood-brain barrier.
An important feature of diphenhydramine is its sedative effect, which has some similarities with the action of antipsychotics; in appropriate doses, it has a hypnotic effect. It is also a moderate antiemetic. In the action of diphenhydramine on the nervous system, its central cholinolytic activity, along with the effect on histamine receptors (possibly, H 3 receptors of the brain), is essential.
Diphenhydramine is mainly used in the treatment of urticaria, hay fever, serum sickness, hemorrhagic vasculitis (capillarotoxicosis), vasomotor rhinitis, angioedema, pruritic dermatoses, acute iridocyclitis, allergic conjunctivitis and other allergic diseases, various allergies, allergies, allergies .
Like other antihistamines, diphenhydramine is used in the treatment of radiation sickness.
In bronchial asthma, diphenhydramine is relatively little active, but it can be prescribed for this disease in combination with theophylline, ephedrine and other drugs.
Sometimes diphenhydramine is used for gastric ulcer and hyperacid gastritis, however, H 2 receptor blockers are much more active in this disease (see Cimetidine, Ranitidine).
Diphenhydramine (as well as other blockers of H 1 receptors) can be used to reduce adverse reactions during transfusion of blood and blood-replacing fluids, with the use of enzyme and other drugs.
Diphenhydramine is also used for chorea, sea and air sickness, vomiting of pregnant women, Meniere's syndrome. The therapeutic effect of the drug in these diseases can be explained in its sedative and central cholinolytic effect. By antiemetic activity, its complex salt with chlorteophylline (dimenhydrinate) is more effective than diphenhydramine.