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Description medicines: Astemizole (Astemizole)

Astemizole (Astemizole) *. 1- (p-Fluorobenzyl) -2 - [[1- (p-metoksifeniletil) -4-piperidyl] amino] benzimidazole.

Synonyms: Gismanal, Alermizol, Astelong, Nismanal, Nistamanal, Ifirab, Lembil, Stemiz, Vagran.

Blocker H 1 histamine receptors.

It binds to muscarinic receptors and dopamine, have weak activity antiserotoninovoy. It does not have a sedative effect not potentiate the action of hypnotics and sedatives, analgesics.

It features high activity and duration of action. If ingestion is rapidly absorbed. Peak plasma concentrations observed after 1 - 4 hours after administration. Withdrawal from the body lasts up to 10 - 14 days.

Partly unmodified astemizole and its metabolites are excreted primarily in the feces. Through not penetrate the blood brain barrier.

Bioavailability astemizole reduced when taken with food.

Applied for the treatment of seasonal rhinitis (hay fever), allergic conjunctivitis, skin itching and other allergic symptoms.

Assign adults and children over 12 years of age at a dose of 10 mg (0.01 g), 1 time per day on an empty stomach. If necessary, increase the daily dose to 30 mg. The maximum period of 7 days of receiving the drug.

Children aged 6 - 12 years give 5 mg per day (half tablets); if necessary - to 15 mg per day, for a maximum of 7 days. For children under 6 years - 2 mg (2 mL slurry) per 10 kg body weight.

When receiving astemizole side effects are not usually observed, but perhaps increased appetite with weight gain.

In pregnancy, the drug is not prescribed.

Astemizole has no effect on the action of corticosteroids, antibiotics, sulfonamides, diuretics, analgesics, cardiovascular medications.

Method of production: tablets of 0.01 g (10 mg) in a package of 10 pieces; suspension containing 5 mL (1 teaspoon) 0.005 g (5 mg) of the drug, in vials of 50 ml.

Storage: List B.