Description of the medicine: Astemizole (Astemizole)
ASTEMIZOL (Astemizole) *. 1- (para-fluorobenzyl) -2 - [[1- (para-methoxyphenylethyl) -4-piperidyl] amino] benzimidazole.
Synonyms: Gismanal, Аlermizol, Аstelong, Нismanal, Нistamanal, Ifirab, Lembil, Stemiz, Vagran.
Blocker of H 1 histamine receptors.
It does not bind to muscarinic and dopamine receptors; it has weak antiserotonin activity. It does not have a sedative effect, does not potentiate the effects of sleeping pills and sedatives, analgesics.
It is characterized by high activity and duration of action. When taken orally, it is rapidly absorbed. Peak plasma concentrations are observed 1 to 4 hours after administration. Excretion from the body lasts up to 10 - 14 days.
Partially unchanged astemizole and its metabolites are excreted mainly with feces. It does not cross the blood-brain barrier.
The bioavailability of astemizole decreases when taken with food.
It is used to treat seasonal rhinitis (pollinosis), allergic conjunctivitis, skin itching and other allergic manifestations.
Assign to adults and children over 12 years old at a dose of 10 mg (0.01 g) once a day on an empty stomach. If necessary, increase the daily dose to 30 mg. The maximum period for taking the drug is 7 days.
Children aged 6 to 12 years are given 5 mg per day (1/2 tablet); if necessary - 15 mg per day, for a maximum of 7 days. Children under 6 years old - 2 mg (2 ml of suspension) per 10 kg of body weight.
When taking astemizole, side effects are usually not observed, but an increase in appetite with an increase in body weight is possible.
During pregnancy, the drug is not prescribed.
Astemizole does not affect the action of corticosteroids, antibiotics, sulfonamides, diuretics, analgesics, cardiovascular drugs.
Method of release: tablets of 0.01 g (10 mg) in a package of 10 pieces; suspension containing 5 ml (1 teaspoon) of 0.005 g (5 mg) of the drug in 50 ml vials.
Storage: List B.