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Description medications: Omeprazole (Omeprazole)

OMEPRAZOLE (Omeprazole) *. 5-Methoxy-2 - [[(4-methoxy-3, 5-dimethyl-2-pyridyl) methyl] sulfinyl] benzimidazole.

Synonyms: Losec, Omeprol.

The chemical structure has some similarities with cimetidine but blocking effect on H2 receptors has not. However, a very effective anti-ulcer agent. The drug is very lipophilic, easily penetrates the parietal cells of the gastric mucosa, and concentrates them exerts a cytoprotective effect; It protects the mucous membrane of the stomach and duodenum. It is believed that the anti-ulcer effect of omeprazole is mainly due to the blockade "acid pump", with a decrease in the secretion of stomach acid, which is associated with the inhibition of Na + -K + -ATPase in the parietal cell membranes.

Apply omeprazole in severe peptic ulcers occurring, not amenable to treatment with other anti-ulcer agents, with erosive reflux esophagitis, Zollinger at - Ellison.

Assign inside. Typical dosages for gastric one 20 mg once a day (sometimes 40 mg per day); duodenal ulcer and erosive reflyuksezofagite 20 mg per day; when Zollinger - Ellison from 20 to 60 mg or more (up to 120 mg) per day (two doses). The course of treatment lasts an average of 4 weeks.

When using omeprazole possible dyspeptic symptoms and other side effects. The drug enhances the effect of coumarin and difenina, inhibits the release of benzodiazepines (diazepam or sibazona).

Contraindications: pregnancy and breast-feeding.

Product: Capsules containing 0.02 g (20 mg) in the form of pellets of omeprazole.

Storage: List B.