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Description of the medicine: Omeprazole (Omeprazole)

Omeprazole (Omeprazole) *. 5-Methoxy-2 - [[(4-methoxy-3, 5-dimethyl-2-pyridyl) methyl] sulfinyl] benzimidazole.

Synonyms: Losec, Omeprol.

The chemical structure has some elements of similarity with cimetidine, but does not have a blocking effect on H2 receptors. However, it is a very effective anti-ulcer agent. The drug is very lipophilic, easily penetrates into the parietal cells of the gastric mucosa, concentrates in them and has a cytoprotective effect; protects the mucous membrane of the stomach and duodenum. It is believed that the antiulcer effect of omeprazole is mainly associated with the blockage of the "acid pump", with a decrease in the secretion of stomach acid, which is associated with inhibition of Na + -K + -ATPase in the membranes of parietal cells.

Omeprazole is used for severely flowing peptic ulcers that cannot be treated with other anti-ulcer drugs, for erosive reflux esophagitis, and for Zollinger-Ellison syndrome.

Assign inside. Usual doses for gastric ulcer 20 mg 1 time per day (sometimes 40 mg per day); with duodenal ulcer and erosive reflux esophagitis, 20 mg per day; with Zollinger-Ellison syndrome, from 20 to 60 mg or more (up to 120 mg) per day (in 2 doses). The course of treatment lasts an average of 4 weeks.

When using omeprazole, dyspeptic symptoms and other side effects are possible. The drug enhances the effect of coumarins and diphenin, slows down the release of benzodiazepines (diazepam, or sibazon).

Contraindications: pregnancy and lactation.

Release form: capsules containing 0.02 g (20 mg) of omeprazole in the form of granules.

Storage: List B.