Description medications: Cromolyn sodium (Cromolyn sodium)

Cromolyn sodium (Cromolyn sodium) *.

Disodium salt of 5, 5'- [(2-oksitrimetilen) dioxy bis (4-oxo) -4H-1-benzopyran-2-carboxylic acid], or the 5, 5 '- (2-oksitrimetilendioksi disodium salt), bis (4 -oxo) -4H-chromene-2-carboxylic acid.

Synonyms: Intal, sodium cromoglycate, Alecrom, Bicromat, Cromoral, Disodium cromoglycate, Fluvet, Frenal, Inostral, Ifiral, Intal, Introl, Kromolin, Lomudal, Lomupren, Lomusol, Nasmil, Nedocromil sodium, Opticrom, Rynacron, Sodium cromoglicate, Vicrom, Vistacrom, Vividrin and others.

Cromolyn sodium is a specific tool used in bronchial asthma and bronchospastic conditions. At the heart of its action is the ability to inhibit the degranulation of mast cells (mast cells), mucous membranes of the respiratory tract and delay the release of these substances mediator promoting bronhiolospazma, allergy and inflammation (bradykinin, "slow reacting substance", histamine, etc.). It is possible that the action of the drug is also related in part to the blockade of receptors specific mediators of inflammation, as well as choline and adrenomediatorov lymphoid cells. The properties of conventional receptor blockers cromolyn sodium has.

Action cromolyn sodium is clearly manifested when applied topically in the form of inhalations. When administered effect does not develop.

Cromolyn sodium is effective in patients with bronchial asthma and has a preventive action when applied to the development of bronchial asthma attack. Continuous long-term use of the drug slows and simplifies asthma attacks, reduces the need for bronchodilators and corticosteroids. For treatment of acute attacks of the drug is not used. Cromolyn sodium is most effective in patients with a relatively young age, who have not yet developed chronic changes in the lung. The drug is most pronounced in atopic form of bronchial asthma, but the effect is also observed in infectious form of allergic disease in asthmatic bronchitis, pnevmoskleroze with bouts of choking, especially in the presence of an allergic component.

The drug is used in powder form in capsules for inhalation. Each capsule contains 0.02 g (20 mg), cromolyn sodium. Spray powder and inhaling produces a special pocket turboingalyatora ( "Spingaler"), which put the capsule with the drug. Clicking on the top (cover) of the inhaler and the capsule is pierced by inhalation powder is inhaled. To empty the capsule requires 4 energetic inspiration.

Inhalation produce daily. Beginning with the application of one capsule four times a day at intervals of 4 -. 6 h sometimes severe cases, the dose was increased to 8 capsules per day (every 3 hours for one capsule). After improving the number of inhalations gradually, selecting an effective maintenance dose.

Cromolyn sodium can be used in conjunction with bronchodilators and corticosteroids.