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Description of the medicine: Ketotifen (Ketotifenum)

KETOTIFEN (Ketotifenum) *. 4, 9-dihydro-4- (1-methyl-4-piperidinylidene-10H-benzo [4, 5] cyclohepta [1, 2-b] thiophen-10-one [hydrofumarate).

Synonyms: Astafen, Zaditen, Asmasedil, Asmen, Astafen, Histaten, Ketotisin, Poziten, Respimex, Totifen, Zaditen, Zasten.

The drug has antihistamine and antiallergic activity. The action is associated with the ability to inhibit the release of histamine and other mediators (“slow-reacting anaphylaxis substance”, lymphokines, etc.) from mast cells, suppress platelet-induced activation factor of eosinophils in the airways, and have a blocking effect on β-receptors.

The drug is well absorbed, a peak in plasma concentration is observed 2 to 4 hours after ingestion, the elimination half-life reaches 21 hours.

It is used to treat (mainly to prevent attacks) bronchial asthma, allergic bronchitis, hay fever, allergic rhinitis, allergic skin reactions.

Assign inside adults to 0.001 g (1 mg) in the form of capsules or tablets 2 times a day (morning and evening with meals). If necessary, take 2 mg 2 times a day.

Children, depending on age and body weight, are prescribed in smaller doses (1/3 - 1/2 - 1 tablet 2 times a day).

The drug can have a sedative effect and should be prescribed with caution to drivers of transport, operators, etc. It should be borne in mind that the drug enhances the effect of sleeping pills, sedatives and alcohol. A decrease in platelet count is possible.

The drug is contraindicated in pregnancy. It should not be prescribed simultaneously with oral antidiabetic and other drugs that can cause thrombocytopenia. Persons sensitive to sedation are prescribed the drug in the first weeks of treatment in reduced doses - 0.0005 g (0.5 mg) per day.

Method of release: capsules and tablets of 0.001 g (1 mg); syrup containing in 1 ml 0.2 mg of the drug (in 100 ml 20 mg).

Storage: List B.