Medication Description: Ketotifen (Ketotifenum)
KETOTHIPHENE (Ketotifenum) *. 4, 9-Dihydro-4- (1-methyl-4-piperidinylidene-10H-benzo [4, 5] cyclohepta [1, 2-b] -thiophene-10-one [hydrofumarate).
Synonyms: Astafen, Zaditen, Asmasedil, Asmen, Astafen, Histaten, Ketotisin, Poziten, Respimex, Totifen, Zaditen, Zasten.
The drug has antihistamine and antiallergic activity. The action is associated with the ability to inhibit the release of histamine and other mediator substances ("slow-reacting substance of anaphylaxis", lymphokines, etc.) from mast cells, to suppress the accumulation of platelet-induced eosinophils in the respiratory tract, to exert a blocking effect on α-receptors.
The drug is well absorbed, the peak concentration in the blood plasma is noted after 2 to 4 hours after ingestion, the half-life reaches 21 hours.
Used for the treatment (mainly for the prevention of attacks) of asthma, allergic bronchitis, hay fever, allergic rhinitis, allergic skin reactions.
Assign inside adults to 0.001 g (1 mg) in the form of capsules or tablets 2 times a day (morning and evening with meals). If necessary, take 2 mg 2 times a day.
Depending on age and body weight, children are prescribed in smaller doses (1/3 - 1/2 - 1 tablet 2 times a day).
The drug can have a sedative effect and should be prescribed with caution to drivers of transport, operators, etc. It should be borne in mind that the drug enhances the effect of sleeping pills, sedatives and alcohol. Perhaps a decrease in the number of platelets.
The drug is contraindicated in pregnancy. It should not be administered simultaneously with oral antidiabetic and other drugs that can cause thrombocytopenia. Persons sensitive to sedative action, prescribe the drug in the first weeks of treatment in reduced doses - 0.0005 g (0.5 mg) per day.
Method of production: capsules and tablets of 0.001 g (1 mg); syrup containing in 1 ml of 0.2 mg of the drug (in 100 ml of 20 mg).
Storage: List B.