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Description of the medicine: Serotonin adipinate (Serotonini adipinas)

SEROTONINA ADIPINATE (Serotonini adipinas).

For use in medical practice, serotonin is produced synthetically. 3a abroad is produced in the form of creatinine-sulfate, in our country - in the form of adipate.

Synonyms for serotonin of creatinine sulfate: Anthemovister, Enteramin, Thrombocytin, Thrombotonin.

Serotonin adipate is a white or white with a creamy hue of crystalline powder. It is soluble in water, it is difficult - in alcohol.

According to the pharmacological properties of serotonin, adipate does not differ from serotonin of creatinine sulfate, but adipate is more stable and more soluble in water.

In general, serotonin is used as an antihemorrhagic agent. The effect is associated with peripheral vasoconstrictive action, the ability to increase platelet aggregation and shorten the time of bleeding.

Serotonin adipate is used to treat hemorrhagic syndrome under various pathological conditions, including Verlhof disease, hypo-aplastic anemia, thrombasthenia, hemorrhagic vasculitis, hemorrhagic syndrome after cytostatic treatment, malignant neoplasms and other diseases. Serotonin helps increase the resistance of capillaries and reduce the duration of bleeding.

Enter intravenously or intramuscularly. With severe bleeding begin with intravenous administration, and with a decrease in bleeding, they switch to intramuscular injections.

The initial dose is 0.005 g (5 mg); In the absence of side effects increase the dose to 0.01 g.

For intravenous infusions, dilute the preparation (5-10 mg) in 100-150 ml of isotonic sodium chloride solution (or in 5-10 ml of isotonic sodium chloride solution, which are then diluted in 100-150 ml of 5% glucose solution, plasma, canned blood) And injected drip (not more than 30 drops per minute).

For intramuscular injections, 5-10 mg is diluted in 5 ml of a 0.5% novocaine solution; Enter 2 times a day at intervals of at least 4 hours.

The daily dose for an adult is 0.015-0.02 g (15-20 mg). The average course of treatment is 10 days.

It should be borne in mind that the rapid introduction of serotonin into the vein and its administration in these doses in a small volume of fluid can cause pain along the veins, abdominal pain, unpleasant sensations in the heart, increased blood pressure, heaviness in the head, difficulty breathing, nausea, diarrhea , Decreased diuresis. Usually these reactions go without complications. With severe side effects, antihistamines and antiallergic drugs are recommended. With intramuscular injection, pain at the injection site is possible.