Description of the medicine: Serotonin adipate (Serotonini adipinas)
SEROTONIN ADIPINATE (Serotonini adipinas).
For use in medical practice, serotonin is obtained synthetically. Abroad, it is produced in the form of creatinine sulfate, in our country in the form of adipate.
Synonyms of serotonin creatinine sulfate: Anthemovister, Enteramin, Thrombocytin, Thrombotonin.
Serotonin adipate is a crystalline powder, white or white with a creamy tint. Soluble in water, difficult in alcohol.
According to the pharmacological properties of serotonin, adipate does not differ from serotonin creatinine sulfate, but adipate is more resistant and more soluble in water.
Mostly serotonin is used as an antihemorrhagic agent. The effect is associated with a peripheral vasoconstrictor effect, the ability to increase platelet aggregation and shorten bleeding time.
Serotonin adipate is used to treat hemorrhagic syndrome in various pathological conditions, including Werlhof’s disease, hypoplastic anemia, thrombasthenia, hemorrhagic vasculitis, hemorrhagic syndrome after treatment with cytostatic agents, for malignant neoplasms and other diseases. Serotonin helps increase the resistance of capillaries and reduce the duration of bleeding.
Enter intravenously or intramuscularly. With severe bleeding, they begin with intravenous administration, and with a decrease in bleeding, they switch to intramuscular injections.
The initial dose is 0.005 g (5 mg); in the absence of side effects, increase the dose to 0.01 g.
For intravenous infusions, the drug (5-10 mg) is diluted in 100-150 ml of isotonic sodium chloride solution (or 5-10 ml of isotonic sodium chloride solution, which is then diluted in 100-150 ml of 5% glucose solution, plasma, canned blood) and injected dropwise (not more than 30 drops per minute).
For intramuscular injections, 5-10 mg is diluted in 5 ml of a 0.5% solution of novocaine; administered 2 times a day at intervals of at least 4 hours
The daily dose for an adult is 0.015-0.02 g (15-20 mg). The course of treatment is an average of 10 days.
It should be borne in mind that the rapid introduction of serotonin into the vein and its administration in the indicated doses in a small volume of liquid can cause pain along the vein, abdominal pain, discomfort in the heart, increased blood pressure, heaviness in the head, difficulty breathing, nausea, diarrhea , decreased urine output. Usually these reactions go without complications. With severe side effects, the use of antihistamines and anti-allergic drugs is recommended. With intramuscular injection, pain at the injection site is possible.