Medication Description: Serotonin Adipate (Serotonini adipinas)
SEROTONINA ADIPINAT (Serotonini adipinas).
For use in medical practice, serotonin is produced synthetically. 3 abroad is produced in the form of creatinine sulfate, in our country - in the form of adipinate.
Synonyms of serotonin creatinine sulfate: Anthemovister, Enteramin, Thrombocytin, Thrombotonin.
Serotonin adipate is a crystalline powder, white or white with a creamy tint. Soluble in water, it is difficult - in alcohol.
According to the pharmacological properties of serotonin, adipate does not differ from serotonin creatinine sulfate, but adipate is more stable and better soluble in water.
Mostly serotonin is used as an antihemorrhagic agent. The effect is associated with peripheral vasoconstrictor action, the ability to increase platelet aggregation and shorten the bleeding time.
Serotonin adipate is used to treat hemorrhagic syndrome in various pathological conditions, including Verlgof's disease, hypois of aplastic anemia, thrombastia, hemorrhagic vasculitis, hemorrhagic syndrome after treatment with cytostatic drugs, in malignant tumors and in other diseases. Serotonin helps to increase the resistance of capillaries and reduce the duration of bleeding.
Enter intravenously or intramuscularly. In case of severe bleeding, they begin with intravenous administration, and with a decrease in bleeding, they switch to intramuscular injections.
Initial dose - 0.005 g (5 mg); in the absence of side effects, increase the dose to 0.01 g.
For intravenous infusions, dilute the drug (5–10 mg) in 100–150 ml of isotonic sodium chloride solution (or in 5–10 ml of isotonic sodium chloride solution, which are then diluted in 100–150 ml of 5% glucose, plasma, canned blood) and injected drip (not more than 30 drops per minute).
For intramuscular injections, 5-10 mg is diluted in 5 ml of a 0.5% solution of novocaine; administered 2 times a day at intervals of not less than 4 hours
The daily dose for an adult is 0.015-0.02 g (15-20 mg). The course of treatment is on average 10 days.
It should be borne in mind that the rapid introduction of serotonin into the vein and its introduction in the indicated doses in a small volume of fluid can cause pain along the vein, pain in the abdomen, discomfort in the region of the heart, increased blood pressure, heaviness in the head, difficulty breathing, nausea, diarrhea , decrease in diuresis. Usually these reactions go without complications. With pronounced side effects, the use of antihistamine and antiallergic drugs is recommended. With intramuscular injection, pain at the injection site is possible.