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Description medications: Mexamine (Mexaminum)
Mexamine (Mexaminum). 5-methoxytryptamine hydrochloride.
White, with a creamy white crystalline powder.
Easily soluble in water, it is difficult - in alcohol.
On chemical structure and pharmacological properties similar to serotonin mexamine.
Like serotonin, causing constriction of peripheral blood vessels, contraction of smooth muscles of internal organs. Also it has a sedative effect and enhances the action of hypnotics and analgesics.
An important feature is its mexamine radioprotective activity (see. For the treatment and prevention of radiation sickness). In experimental conditions animals it lowers mortality exposed to X-ray or gamma radiation as well as high energy protons. The radioprotective effect of the mechanism is important, presumably caused by hypoxia in the preparation of "critical" organs -. Bone marrow, spleen, etc. that is possibly connected with the narrowing in the blood vessels of organs.
In patients undergoing radiotherapy for malignant tumors, pre-ingestion mexamine reduces the effects of radiation response.
Applied for the prevention of general radiation reactions during radiation therapy. Assign inside of 0.05 g (1 tablet) for 30 - 40 minutes before each session of radiation therapy. dosage can be increased with good endurance to 0.1 g
The drug is generally well tolerated. In some cases, possible mild nausea, dizziness, pain in the epigastric region, sometimes vomiting. Side effects can be reduced when using caffeine. When poor tolerability continued taking the drug is stopped.
Contraindicated in patients with severe sclerosis of the heart and blood vessels of the brain, cardiovascular disease, asthma, kidney disease with infringement of their function during pregnancy.
Product: tablets of 0.05 g (50 mg) was coated.
Storage: List B. In the dark glass jars in a dry, dark place.
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