Description of the medicine: Ketanserinum (Ketanserinum)

KETANSERINUM. 3- [2- [4- (p-Fluorobenzoyl) piperidinyl] ethyl] -2,4 (1H, 3 H) -quinazolinedione.

Synonyms: Suffroxal, Serefrex, Sufrexal, Sufroxal.

Available in the form of tartrate.

White or slightly yellowish powder.

It is a specific antagonist of 5-HT 2 -receptors; In addition, has a moderate a-adrenoblocking effect.

Ketanserin blocks various effects of serotonin, especially its spasmogenic effect on vascular and bronchial muscles on platelet aggregation.

In connection with the combined blocking effect on 5-HT 2 (S 2) -gistamine and a 1 -adrenergic receptors, the drug causes vasodilation and has an antihypertensive effect.

Ketanserin is used in the treatment of hypertension, for the relief of hypertensive crises, as well as for violations of peripheral circulation (intermittent claudication, Raynaud's disease, etc.). Assign also with thrombosis (peripheral thrombophlebitis, hemorrhoidal thrombosis, etc.).

In acute hypertensive crises, 10 mg (2 ml of a 0.5% solution) or intravenously at a dose of 10-30 mg (2-6 ml at a rate of 5 mg per minute) are administered intramuscularly.

After a single (bolus) administration, intravenous infusion is administered at a dose of 2-6 mg / h. Inside with hypertension and spasms of peripheral vessels appoint 20 to 40 mg 2 times a day (during meals). Elderly people are prescribed 20 mg twice a day.

There are data on the use of ketanserin in the complex therapy of chronic bronchitis (administered intravenously at 10 mg per day for 7 days, then administered internally at 20 mg per day).

When using ketanserin, one should consider the possibility of severe hypotension during parenteral administration; The patient should be in a prone position in these cases.

The drug is contraindicated: during pregnancy and lactation.

Forms of release: tablets of 20 and 40 mg; 0.5% solution in ampoules of 2 and 10 ml (10 or 50 mg each).

Storage: List B. At room temperature.