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Description of the medicine: Ketanserin (Ketanserinum)

KETANSERIN (Ketanserinum) *. 3- [2- [4- (para-Fluorobenzoyl) piperidinyl] ethyl] -2, 4 (1H, 3H) -quinazolinedione.

Synonyms: Sufroxal, Serefrex, Sufrexal, Sufroxal.

Available in the form of tartrate.

White or slightly yellowish powder.

It is a specific antagonist of 5-HT 2 receptors; in addition, it has a moderate a-blocking effect.

Ketanserin blocks the various effects of serotonin, especially its spasmogenic effect on the muscles of blood vessels and bronchi, the effect on platelet aggregation.

Due to the combined blocking effect on 5-HT 2 (S 2) -histamine and a 1 -adrenergic receptors, the drug causes the expansion of blood vessels and has an antihypertensive effect.

Ketanserin is used in the treatment of arterial hypertension, for the relief of hypertensive crises, as well as for peripheral circulation disorders (intermittent claudication, Raynaud's disease, etc.). It is also prescribed for thrombosis (peripheral thrombophlebitis, hemorrhoidal thrombosis, etc.).

In acute hypertensive crises, 10 mg is administered intramuscularly (2 ml of a 0.5% solution) or intravenously at a dose of 10-30 mg (2-6 ml at a rate of 5 mg per minute).

After a single (bolus) administration, an intravenous infusion is carried out at a dose of 2-6 mg / h. Inside, with hypertension and spasms of peripheral vessels, 20 to 40 mg are prescribed 2 times a day (with meals). Elderly people are prescribed 20 mg 2 times a day.

There is evidence of the use of ketanserin in the complex treatment of chronic bronchitis (administered intravenously at 10 mg per day for 7 days, then administered orally at 20 mg per day). ''

When using ketanserin, the possibility of severe hypotension with parenteral administration should be considered; the patient should in these cases be in a prone position.

The drug is contraindicated: during pregnancy and lactation.

Method of release: tablets of 20 and 40 mg; 0.5% solution in ampoules of 2 and 10 ml (10 or 50 mg).

Storage: List B. At room temperature.