Medication Description: Ketanserin (Ketanserinum)
KETANSERIN (Ketanserinum) *. 3- [2- [4- (para-Fluorobenzoyl) piperidinyl] ethyl] -2, 4 (1H, 3H) -quinazolinedione.
Synonyms: Sufroxal, Serefrex, Sufrexal, Sufroxal.
Available in the form of tartrate.
White or slightly yellow powder.
It is a specific 5-HT 2 receptor antagonist; in addition, it has a moderate a-blocking effect.
Ketanserin blocks various effects of serotonin, especially its spasmogenic effect on the muscles of the blood vessels and bronchi, the effect on platelet aggregation.
In connection with the combined blocking effect on 5-HT 2 (S 2) -histamine and a 1 -adrenergic receptors, the drug causes dilation of blood vessels and has an antihypertensive effect.
Ketanserin is used in the treatment of hypertension, for the relief of hypertensive crises, as well as in disorders of the peripheral circulation (intermittent claudication, Raynaud's disease, etc.). It is also prescribed for thrombosis (peripheral thrombophlebitis, hemorrhoidal thrombosis, etc.).
In acute hypertensive crises, intramuscular injection of 10 mg (2 ml of a 0.5% solution) or intravenously at a dose of 10–30 mg (2–6 ml at a rate of 5 mg per minute) is administered.
After a single (bolus) injection, intravenous infusion is administered at a dose of 2-6 mg / h. Inside with hypertension and spasms of peripheral vessels, 20-40 mg 2 times a day (with meals) are prescribed. Elderly appoint 20 mg 2 times a day.
There is evidence of the use of ketanserin in the complex therapy of chronic bronchitis (administered intravenously, 10 mg per day for 7 days, then administered orally at 20 mg per day).
When using ketanserin, one should consider the possibility of severe hypotension when administered parenterally; in these cases the patient should be in a prone position
The drug is contraindicated: during pregnancy and breastfeeding.
Method of production: tablets of 20 and 40 mg; 0.5% solution in ampoules of 2 and 10 ml (10 or 50 mg each).
Storage: List B. At room temperature.