Medication Description: Trimecain (Trimecainum)
TRIMEKAIN (Trimecainum). a-Diethylamino-2, 4, 6-trimethylacetanilide hydrochloride.
Synonyms: Mesdicain, Mesidicaine, Mesocain, Trimecaini hydrochloridum.
White or white with a faint yellowish sheen crystalline powder. Very easily soluble in water, easily in alcohol. Solutions (pH 4, 5 5.2) are prepared in isotonic sodium chloride solution, sterilized at + 100 ° C for 30 minutes.
In terms of chemical structure and pharmacological properties, trimekain is similar to lidocaine. Chemically different from lidocaine by the presence of a methyl group at position 4 of the phenyl core.
Trimekain is an active local anesthetic agent.
It causes a rapidly advancing, deep, continuous infiltration, conduction, epidural and spinal anesthesia; in higher concentrations (2–5%) - and surface anesthesia.
Trimekain acts more strongly and longer than Novocain. Relatively little toxic, non-irritating.
For infiltration anesthesia, trimekain is used as a 0.125% solution (up to 1500 ml), 0.25% (up to 800 ml) or 0.5% solution (up to 400 ml). The total dose of the drug for adults should not exceed 2 g.
For conduction anesthesia, use 1% solution (up to 100 ml) and 2% solution (up to 20 ml); for epidural - 1%; 1, 5% or 2% solution (sometimes mixed with autologous blood); Adrenaline is added (0.1% solution of epinephrine hydrochloride in 5-8 drops per 20-25 ml of trimecaine solution). Enter cautiously - fractionally: 1% solution - first in a dose of 5 ml, then 10 ml (total up to 50 ml); 2% solution - up to 20 - 25 ml.
For spinal anesthesia, a 5% solution (2–3 ml) is used, and for a surface anesthesia, 2–5% solutions: in ophthalmic practice, 4 to 8 drops, in otorhinolaryngology, 2 to 8 drops each (with the addition of 0.1% epinephrine hydrochloride: 1 drop for every 2 ml of trimekain solution).
Trimekain is also prescribed as an antiarrhythmic agent. The mechanism of action and indications for use are the same as for lidocaine. However, trimekain is less effective than lidocaine.
The methods of administration and doses of trimecain when used as an antiarrhythmic agent are approximately the same as for lidocaine: usually 80-120 mg (as a 2% solution) is usually administered intravenously at the rate of 2 mg per minute. (0.1 - 0.2% solution in isotonic sodium chloride solution).
Trimecain is usually well tolerated, with an overdose of possible side effects, like novocaine.
Method of issuance: powder; 0.25% solution in 10 ml ampoules; 0.5% and 1% solutions in 2, 5 and 10 ml ampoules; 2% solution - 1; 2; 5 and 10 ml and 5% solutions - 1 and 2 ml.
Storage: List B.
Trimekain is a part of the aerosol preparation "Tzimezol" (see Tsiminal).