Medication Description: Pyromecain (Pyromecainum)
Pyromecain (Pyromecainum). 2, 4, 6-Trimethylanilide-1-butyl-pyrrolidinecarboxylic-2-acid hydrochloride, or 1-butyl-2, 4, 6-trimethyl-2-pyrrolidinecarboxanilide.
Synonyms: Bumecain hydrochlorid, Bumecaini hydrochloridum, Pirromecain.
White or white with a faint cream tinge crystalline powder. Let's dissolve in water, it is easy - in alcohol. Solutions (pH 2% solution 4, 4–5, 4) are prepared in isotonic sodium chloride solution, sterilized at +100 ° C for 30 minutes.
Local anesthetic. On chemical structure has similarities with trimekainom. It also has an antiarrhythmic effect.
As an anesthetic, it is used for surface anesthesia.
In ophthalmic practice using a 0.5% solution of 1 to 2 drops; in otorhinolaryngological practice - 1 - 5 ml of 1 - 2% solution (if necessary, add 0.1% solution of epinephrine hydrochloride 1 drop for every 2 - 3 ml of pyromecain); for anesthesia with endoscopic studies - 2 - 5 ml of 2% solution; in dentistry - 1 - 5 ml of 1 - 2% solution or 5% pyromecaine ointment.
As an antiarrhythmic agent, pyromecain is prescribed for ventricular arrhythmias: for myocardial infarction, cardiac glycoside intoxication, etc. The pyromecain is administered intravenously as a 1% solution in a 5% glucose solution in a jet of slowly 50 ml / min at a dose of 50-100 mg (5 - 10 ml of 1% solution) for 3 - 5 min. For long-term therapy, pyromecain is administered intravenously in a stream-like manner slowly at a rate of 1 ml / min at a dose of 100 mg (10 ml of solution) 2 to 3 times with an interval between injections of 15 to 20 minutes. The achieved antiarrhythmic effect is supported by the drip of the drug at a rate of 2–3 mg / min (8–12 drops per minute). In acute myocardial infarction, pyromecain is administered: 1) at a dose of 100–150 mg (10–15 ml of a 1% solution) slowly intravenously over a period of 3-5 minutes (a single bolus); 2) at a dose of 100 mg (10 ml of 1% solution) 2 times with an interval between injections of 15–20 minutes against the background of drip administration — twice a bolus against the background of an infusion.
The duration of the infusion depends on the nature and course of the process and the effectiveness of therapy.
The average single dose for intravenous administration of a 1% solution of 0.1 g (100 mg).
The highest daily dose with the introduction of a vein - 1, 5 g (1500 mg).
When pyromecaine is used, general weakness, nausea, vomiting, dizziness, a drop in blood pressure, a collaptoid state are possible. If necessary, recommended vasoconstrictor. Intravenous administration should be carried out only in a hospital.
Forms of release: 0,5%; 1% and 2% solutions in 10 ml ampoules, 1% solution in 5% glucose solution for intravenous administration (Sol. Pomemecaini 1% cum glucoso pro injectionibus) in 10 ml ampoules; 5% pyromecaine ointment.
Storage: List B.
Pyromecaine ointment 5% (Unguentum Pyromecaini 5%). Used as an anesthetic for inflammatory diseases of the oral mucosa. Apply a thin layer to the painful area once or twice for 2 - 5 minutes. The dose of ointment should not exceed 1 g.
Form release: in tubes of 30 g.