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Medication Description: Chlorali hydrate (Chlorali hydras)

CHLORALHYDRATE (Chlorali hydras). 2, 2, 2-Trichloroethanediol-1, 1

Synonyms: Aquachloral, Chloradorm, Chloraldurat, Chloral hydrate, Chloratol, Dormel, Dormiben, Hydral, Lorinal, Lycoral, Medianox, Noctec, Nycoton, Somnos, Sorosil, etc.

Colorless transparent crystals or fine-crystalline powder with a characteristic spicy eapach and slightly bitter peculiar taste. Very easily soluble in water and alcohol. On air slowly disappears. Hygroscopic.

Sedative, hypnotic and analgesic agent; in large doses, close to toxic, has narcotic properties. It has a complex effect on the central nervous system; in small doses it causes a weakening of the inhibitory processes, in large doses - a decrease in the processes of excitation; toxic doses strongly inhibit the excitability of nerve cells.

Currently rarely used as a sedative (in adults - 0.2 - 0.5 g per reception) or hypnotic (0.5 - 1 g) means. Children, depending on age and indications prescribed by 0.05 - 0.75 g per reception. Is taken orally or injected in enemas in a diluted form with enveloping substances (due to the irritant effect on the mucous membrane of the stomach and intestines). The drug is rapidly absorbed. Sleep begins in 15-20 minutes, lasts 6-8 hours; often accompanied by a decrease in blood pressure; vomiting is possible.

More often, chloral hydrate is used for mental stimulation and as an anticonvulsant for spasmophilia, tetanus, etc.

Also used in children for the intensive treatment of convulsive status. Children under the age of 5 years are prescribed in an enema 15 - 20 ml of 2% solution, older children - 40 - 60 ml of 3% solution. If necessary, enter in 1 to 2 h half the dose. At the same time, phenobarbital and difenin are prescribed.

Higher doses for adults inside and in enema; single 2 g daily 6 g

Contraindicated in severe diseases of the cardiovascular system, liver and kidneys.

With prolonged use may addictive.

Form release: powder.

Included in the tooth drops <Denta>.

Storage: List B. In a well-closed container, protected from light, in a cool place.

Rp .: Chlorali hydratis 1, 0

Mucilaginis amyli

Aq. destill. aa 25 ml

MDS