Description medications: Chloral hydrate (Chlorali hydras)
Chloral hydrate (Chlorali hydras). 2, 2, 2--Trihloretandiol 1, 1
Synonyms: Aquachloral, Chloradorm, Chloraldurat, Chloral hydrate, Chloratol, Dormel, Dormiben, Hydral, Lorinal, Lycoral, Medianox, Noctec, Nycoton, Somnos, Sorosil and others.
Colourless, transparent crystals or crystalline powder with a characteristic sharp and slightly bitter eapahom original taste. Very easily soluble in water and alcohol. In the air escapes slowly. Hygroscopic.
Sedative, hypnotic and analgesic; at high doses, close to the toxic, has narcotic properties. It has a complex effect on the central nervous system; in small doses causes a weakening of inhibitory processes in large - lowering voebuzhdeniya processes; toxic doses greatly inhibit the excitability of nerve cells.
Currently rarely used as a sedative (adults - 0.2 - 0.5 g per dose) or soporific (0.5 - 1g) means. Children, depending on age and the testimony appoint 0,05 - 0,75 g per reception. Taken orally or injected into the enema diluted with overlying materials (due to the irritating effect on the mucous membrane of the stomach and intestines). The drug is rapidly absorbed. Sleep comes in 15 - 20 minutes, lasts 6 - 8 hours; often accompanied by a decrease in blood pressure; possible vomiting.
Most chloral hydrate is used for mental stimulation and as an anticonvulsant agent in spazmofilii, tetanus and so on. N.
Also used in children for intensive therapy of convulsive status. Children under 5 years is prescribed an enema of 15 - 20 mL of 2% solution, older children - 40 - 60 ml of a 3% solution. If necessary, administered in 1 - 2 hours, a half dose. At the same time prescribed phenobarbital and phenytoin.
Higher doses for adults inside and enema; single 2 g daily 6 g
Contraindicated in severe diseases of the cardiovascular system, liver and kidneys.
With long-term use may be addictive.
Included in the dental drops <Dent>.
Storage: List B. The well-closed container, protected from light, in a cool place.
Rp .: Chlorali hydratis 1 0
Aq. destill. aa 25 ml