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Medication Description: Aluminum Hydroxide (Aluminii hydroxydum)

ALUMINUM HYDROXIDE (Aluminii hydroxydum).

Synonyms: Aluminum hydroxydatum, Aluminumium hydroxyde.

Amorphous friable white powder, practically insoluble in water and capable of forming a gel; soluble when heated in dilute acids and solutions of caustic alkalis.

It has antacid, adsorbing and coating properties.

The drug neutralizes hydrochloric (hydrochloric) acid (1 g neutralizes about 250 ml of 0.1N hydrochloric acid solution) to form aluminum chloride and water; The pH of the gastric juice gradually rises to 3, 5 4, 5 and remains at this level for several hours. At this pH, the acidity of the gastric juice not only decreases, but its peptic (proteolytic) activity is also strongly inhibited. In the alkaline contents of the intestinal aluminum chloride forms insoluble (and nonabsorbable) aluminum compounds (phosphates, etc.) and chlorine ions. Chlorine ions are reabsorbed, so alkalosis does not develop.

Inside prescribed aluminum hydroxide with increased acidity of gastric juice, gastric ulcer and duodenal ulcer, acute and chronic hyperacid gastritis and food poisoning.

Inside prescribed in the form of suspensions (4%) in water, usually 1 to 2 teaspoons 4 to 6 times a day.

Nowadays, other preparations containing aluminum, including combined dosage forms, have become more widely used (see Almagel, Gastal, etc.).

With the use of aluminum hydroxide may develop constipation. In combination with magnesium oxide (see Gastal), the antacid effect is enhanced and the possibility of constipation is reduced.

Due to the fact that aluminum hydroxide binds phosphates and delays their absorption from the gastrointestinal tract, it is used in hyperphosphatemia accompanying renal failure. However, there are indications that when pronounced impairment of renal function, aluminum preparations are contraindicated.

Aluminum hydroxide is sometimes used as an astringent externally for skin diseases.

Form release: powder.