Description of the medicine: Aluminum hydroxide (Aluminii hydroxydum)
ALUMINUM HYDROXIDE (Aluminii hydroxydum).
Synonyms: Aluminum hydroxydatum, Aluminum hydroxyde.
Amorphous loose white powder, practically insoluble in water and able to form a gel; soluble when heated in dilute acids and caustic alkali solutions.
It has antacid, absorbent and enveloping properties
The drug neutralizes hydrochloric (hydrochloric) acid (1 g neutralizes about 250 ml of a 0.1 N hydrochloric acid solution) with the formation of aluminum chloride and water; The pH of gastric juice gradually rises to 3, 5, 4, 5 and remains at this level for several hours. At this pH value, not only does the acidity of the gastric juice decrease, but its peptic (proteolytic) activity is also strongly inhibited. In the alkaline contents of the intestines of aluminum, chloride forms insoluble (and non-absorbable) aluminum compounds (phosphates, etc.) and chlorine ions. Chlorine ions are reabsorbed, so alkalosis does not develop.
Inside, aluminum hydroxide is prescribed for increased acidity of gastric juice, peptic ulcer of the stomach and duodenum, acute and chronic hyperacid gastritis, and food poisoning.
Inside, it is prescribed in the form of suspensions (4%) in water, usually 1 to 2 teaspoons 4 to 6 times a day.
At present, other preparations containing aluminum have become more widely used, including combined dosage forms (see Almagel, Gastal, etc.).
When using aluminum hydroxide, constipation may develop. In combination with magnesium oxide (see Gastal), the antacid effect is enhanced and the possibility of constipation is reduced.
Due to the fact that aluminum hydroxide binds phosphates and delays their absorption from the gastrointestinal tract, it finds application in hyperphosphatemia accompanying renal failure. At the same time, there are indications that with severe renal impairment, aluminum preparations are contraindicated.
Aluminum hydroxide is sometimes used as an astringent externally for skin diseases.
Release form: powder.