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Description of the medicine: Baclofen (Baclofen)

BACLOFEN (Baclofen) *. 4-amino-3- (para-chlorophenyl) butyric acid

Synonyms: Lyoresal, Baclon, Gabalon, Lioresal, Spastin.

In structure, baclofen is similar to derivatives of g - aminobutyric acid, aminolone and phenibut (see). It differs from the latter by the presence of a chlorine atom in the para position of the phenyl core.

The pharmacological properties of baclofen are different than that of phenibut and other nootropic drugs (see). He is an agonist of GABA-B receptors, and the main manifestation of its pharmacological activity is an antispastic effect. It inhibits spinal and visceral reflexes, reduces muscle tension, clonus. It also has an analgesic effect.

Baclofen is used to reduce spasticity in multiple sclerosis and other types of spasticity (mainly spinal origin), but not in case of muscle rigidity in patients with parkinsonism.

Baclofen is prescribed orally (during meals), starting with 5 mg 3 times a day, then the dose is increased (every 3 days by 5 mg 3 times a day) to a maximum daily dose of 60 - 75 mg. Cancel the drug should be gradual.

When taking baclofen, nausea, vomiting, dizziness are possible. Like other muscle relaxants, it can impair normal walking ability.

Contraindications: psychosis, epilepsy, Parkinson's disease. Caution is needed for impaired renal function.

Release form: tablets of 10 and 25 mg in a package of 50 pieces.

Storage: List B.