Description of the medicine: Baclofen

Baclofen *. 4-Amino-3- (p-chlorophenyl) -butyric acid

Synonyms: Lioresal, Baclon, Gabalon, Lioresal, Spastin.

The structure of baclofen is similar to the derivatives of g-aminobutyric acid aminolon and phenibut (see). The latter differs from the presence of a chlorine atom in the para position of the phenyl nucleus.

Pharmacological properties of baclofen are different than in phenibut and other nootropic drugs (see). He is an agonist of GABA-B receptors, and the main manifestation of his pharmacological activity is antispastic action. He oppresses spinal and visceral reflexes, reduces muscle tension, clonus. It also has an analgesic effect.

Baclofen is used to reduce spasticity in multiple sclerosis and other types of spasticity (mainly of spinal origin), but not with muscular rigidity in patients with Parkinsonism.

Assign baklofen inside (at meal time), starting with 5 mg 3 times a day, then increase the dose (every 3 days for 5 mg 3 times a day) to a maximum daily dose of 60 to 75 mg. Cancel the drug should be gradual.

When taking baclofen, nausea, vomiting, dizziness are possible. Like other muscle relaxants, it can disrupt the ability to walk normally.

Contraindications: psychosis , epilepsy, Parkinson's disease. Caution is needed for violations of kidney function.

Form release: tablets of 10 and 25 mg in a package of 50 pieces.

Storage: List B.