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Medication Description: Baclofen (Baclofen)

Baclofen (Baclofen) *. 4-amino-3- (para-chlorophenyl) -butyric acid

Synonyms: Lyoresal, Baclon, Gabalon, Lioresal, Spastin.

The structure of baclofen is similar to the derivatives of g-aminobutyric acid aminolone and phenibut (see). It differs from the latter by the presence of a chlorine atom in the para-position of the phenyl core.

The pharmacological properties of baclofen are different than those of phenibut and other nootropic drugs (see). He is an agonist of GABA-B receptors, and the main manifestation of its pharmacological activity is antispastic action. It inhibits spinal and visceral reflexes, reduces muscle tension, clonus. It also has an analgesic effect.

Baclofen is used to reduce spasticity in multiple sclerosis and other types of spasticity (mainly of spinal origin), but not in muscle rigidity in patients with parkinsonism.

Assign baclofen inside (with meals), starting with 5 mg 3 times a day, then increase the dose (every 3 days, 5 mg 3 times a day) to a maximum daily dose of 60 - 75 mg. Cancel the drug should be gradually.

When taking baclofen may nausea, vomiting, dizziness. Like other muscle relaxants, it can impair the ability to walk normally.

Contraindications: psychosis, epilepsy, Parkinson's disease. Caution is needed for violations of the kidneys.

Form release: tablets of 10 and 25 mg in a package of 50 pieces.

Storage: List B.