Description of the medicine: Tizanidine (Tizanidine)

Tizanidine (Tizanidine). 5-Chloro-4- (2-imidazolin-2-yl-amino) -2, 1, 3-benzothiadiazole.

Produced in the form of hydrochloride.

Synonyms: Sirdalud, Sirdalud ("SANDOZ").

White or slightly yellowish fine crystalline powder.

Miorelaxant of central action. Suppresses polysynaptic spinal reflexes and has an antispastic effect with increased muscle tone, relieves spasms and clonic convulsions.

According to its pharmacological properties, tizanidine is similar to midocalam and baclofen, but differs from them in the mechanism of action. Thus, baclofen increases the activity of the inhibitory GABAergic mediator system, and the effect of tizanidine is associated with a decrease in the release of interneurons of excitatory mediator amino acids (see Glutamic acid).

Tizanidine is rapidly and almost completely absorbed when taken orally. The maximum concentration in the blood plasma is observed after 1 to 2 hours. In unchanged form, the drug and metabolites are excreted mainly in the urine.

Tizanidine is used in cases of painful muscular spasms associated with static and functional spine lesions (cervical and lumbar syndrome), and after surgery (for a herniated disc or osteoarthritis of the thigh), as well as spasticity caused by multiple sclerosis, chronic myelopathy, degenerative diseases Spinal cord, stroke, and with convulsions of central origin.

Take tizanidine inside in the form of tablets. For the removal of painful muscle spasm adults are prescribed 2-4 mg (0.002 - 0.004 g) 3 times a day (regardless of the time of eating). If the effect is insufficient, take an additional 2-4 mg at night. In the case of spasticity caused by neurologic disorders, appoint in individually selected doses, starting with a daily dose of 6 mg (in 3 divided doses); Gradually increase the daily dose (with interruptions of 4-7 days) by 2-4 mg. The optimal daily dose is usually 12 to 14 mg (3-4 times). The daily dose should not exceed 36 mg.

Tizanidine is usually well tolerated, but there may be drowsiness, fatigue, dizziness, dry mouth, nausea, a slight decrease in blood pressure. At higher doses, muscle weakness, insomnia, hypotension, bradycardia are possible; In some cases - a temporary increase in the activity of transaminases in the blood serum.

The drug should not be taken during pregnancy and lactation. There is not enough experience in using it in children.

With violations of the liver and kidneys reduce the dose.

In connection with possible drowsiness and muscle weakness, care should be taken when prescribing the drug to persons whose work requires a quick mental and physical reaction (operators, drivers of motor vehicles, etc.).