Description of the medicine: Tizanidine (Tizanidine)
TIZANIDINE (Tizanidine). 5-Chloro-4- (2-imidazolin-2-yl-amino) - 2, 1, 3-benzothiadiazole.
Available in the form of hydrochloride.
Synonyms: Sirdalud, Sirdalud ("SANDOZ").
White or slightly yellow crystalline powder.
Muscle relaxant central action. It suppresses polysynaptic spinal reflexes and has an antispastic effect with increased muscle tone, relieves spasms and clonic convulsions.
According to pharmacological properties, tizanidine is similar to midocalm and baclofen, but differs from them in the mechanism of action. So, baclofen increases the activity of the inhibitory GABAergic mediator system, and the effect of tizanidine is associated with a decrease in the release of exciting mediator amino acids from interneurons (see Glutamic acid).
Tizanidine is rapidly and almost completely absorbed by ingestion. The maximum plasma concentration is observed after 1 - 2 hours. In an unchanged form, the drug and metabolites are excreted mainly in the urine.
Tizanidine is used for painful muscle spasms associated with static and functional lesions of the spine (cervical and lumbar syndromes), and after surgery (for a hernia of the intervertebral disc or hip osteoarthritis), as well as for spasticity due to multiple sclerosis, chronic myelopathy, degenerative diseases spinal cord, stroke and seizures of central origin.
Take tizanidine orally in the form of tablets. To relieve painful muscle spasm, adults are prescribed 2 to 4 mg (0.002 to 0.004 g) 3 times a day (regardless of the meal time). If the effect is insufficient, take an additional 2 to 4 mg at night. With spasticity due to neurological disorders, it is prescribed in individually selected doses, starting with a daily dose of 6 mg (in 3 divided doses); gradually increase the daily dose (with intervals of 4 to 7 days) by 2 to 4 mg. The optimal daily dose is usually 12 to 14 mg (in 3-4 doses). The daily dose should not exceed 36 mg.
Tizanidine is usually well tolerated, but drowsiness, a feeling of fatigue, dizziness, dry mouth, nausea, and a slight decrease in blood pressure can be observed. At higher doses, muscle weakness, insomnia, hypotension, bradycardia are possible; in some cases, a temporary increase in the activity of transaminases in the blood serum.
The drug should not be taken during pregnancy and lactation. There is not enough experience using it in children.
In case of impaired liver and kidney function, the dose is reduced.
In connection with possible drowsiness and muscle weakness, caution should be exercised when prescribing the drug to persons whose work requires a quick mental and physical reaction (operators, drivers of vehicles, etc.).