Description of the medicine: Aminazin (Aminazinum)
AMINAZIN (Aminazinum). 2-Chloro-10- (3-dimethylaminopropyl) - phenothiazine hydrochloride.
Synonyms: Plegomazin, Chlorpromazine, Ampliactil, Amplictil, Chlorazin, Chlorpromazini hydrochloridum, Chlorpromazine hydrochloride, Chlorpromazine, Contomin, Fenactil, Hibanil, Hibernal, Kloproman, Largactil, Megaphen, Plegomazin, dr.
Fine crystalline powder, white or white with a slight cream tint. Slightly hygroscopic. It gets dark in the light. Very soluble in water. Powder and aqueous solutions darken under the influence of light. Solutions have an acid reaction; pH 2, 5% solution 3, 5 - 5, 5.
Sterilization of aqueous solutions can be carried out at + 100 C for 30 minutes, but they are usually not sterilized, since they themselves have bactericidal properties.
Solutions of chlorpromazine (and other phenothiazine preparations) are incompatible with solutions of barbiturates, carbonates, Ringer's solution (precipitation).
Aminazine is one of the main representatives of antipsychotics. Despite the emergence of numerous new antipsychotic drugs, it continues to be widely used in medical practice.
One of the main features of the action of chlorpromazine on the central nervous system is a relatively strong sedative effect. General calming down with an increase in the dose of chlorpromazine is accompanied by a suppression of conditioned reflex activity and, above all, motor-defensive reflexes, a decrease in spontaneous motor activity, and some relaxation of skeletal muscles; a state of reduced reactivity to endogenous and exogenous stimuli occurs; consciousness, however, persists. At high doses, a sleep state may develop.
Aminazine enhances the effect of sleeping pills, drugs, analgesics, and local anesthetics. It inhibits various interoceptive reflexes.
The effect of anticonvulsants under the influence of chlorpromazine is enhanced, but in some cases, chlorpromazine can cause convulsive effects.
The drug has a strong antiemetic effect and soothes hiccups (see also Etaperazin).
Aminazine has a hypothermic effect, especially with artificial cooling of the body. In some cases, in patients with parenteral administration of the drug, body temperature rises, which is associated with the effect on the thermoregulation centers and partially with local irritating effect.
The drug also has moderate anti-inflammatory properties, reduces vascular permeability, reduces the activity of kinins and hyaluronidase. It has a weak antihistamine effect.
An important property of chlorpromazine is its blocking effect on central adrenergic and dopaminergic receptors. It reduces or even completely eliminates the increase in blood pressure and other effects caused by adrenaline and adrenomimetic substances. The hyperglycemic effect of adrenaline with chlorpromazine is not removed. The central adrenolytic effect is strongly expressed. The blocking effect on cholinergic receptors is relatively weak.