Medication Description: Magnesium sulfate (Magnesii sulfas)
MAGNESIUM SULFATE (Magnesii sulfas).
Synonyms: Bitter salt, Magnesium sulfuricum, Sal amarum.
Colorless prismatic crystals, weathered in air, readily soluble in water (1: 1 in cold and 3, 3: 1 in boiling); practically insoluble in alcohol. Aqueous solutions have a bitter-salty taste.
Solutions for injection (pH 6, 2 - 8, 0) are sterilized at +100 'C for 30 minutes, at +120' C for 8 minutes.
Magnesium sulfate has a multifaceted effect on the body. When ingested, it is poorly absorbed, acts as a laxative, like sodium sulfate, and also has a choleretic effect, which is associated with reflexes that occur during stimulation of the nerve endings of the duodenal mucosa.
When parenteral administration of magnesium sulfate has a calming effect on the central nervous system. Depending on the dose, a sedative, hypnotic or narcotic effect may be observed.
One of the features of magnesium sulfate is its depressant effect on neuromuscular transmission. When administered parenterally, especially in large doses, it can have a curare-like effect.
The drug reduces the excitability of the respiratory center, large doses of the drug when administered parenterally can easily cause respiratory paralysis. Blood pressure decreases slightly due to the general sedative effect of the drug; This effect is more pronounced in hypertensive disease.
Magnesium sulfate is excreted by the kidneys, diuresis is enhanced in the process of excretion.
Calcium ion antagonists are calcium ions. A decrease in the calcium content in the blood is accompanied by an increase in the action of magnesium. Calcium salts are used as antidotes for magnesium sulfate poisoning.
Magnesium sulfate is used as a laxative and choleretic agent, and sometimes as a sedative, antispasmodic, and anticonvulsant. It is not used as a narcotic drug due to its low latitude (narcotic doses easily cause paralysis of the respiratory center), but it can be used to enhance the effect of drugs and analgesics.
As a laxative prescribed by mouth (at night or on an empty stomach - for 30 minutes before a meal) for adults 10 - 30 g in 1/2 cup of water, for children - at the rate of 1 g per 1 year of life. In chronic constipation, enemas can be used (100 ml of a 20–30% solution).
As a choleretic take orally 1 tablespoon of 20 - 25% rast thief 3 times a day; duodenal sounding is also performed with the introduction of a warm solution of magnesium sulfate through a probe (50 ml of 25% or 100 ml of 10% solution).
As an antispasmodic (and to some extent antihypertensive) agent is sometimes used in the treatment of early stages of hypertension. Enter intramuscularly at 5 -10 - 20 ml of 20% or 25% magnesium sulfate solution. The course of treatment is 15 to 20 injections (daily). Along with a decrease in blood pressure, there may be a decrease in the symptoms of angina pectoris.