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Description of the medicine: Etaperazin (Aethaperazinum)

ETAPERAZINE (Aethaperazinum). 2-Chloro-10- {3- [1- (b-hydroxyethyl) -piperazinyl-4] -propyl) -phenothiazine dihydrochloride.

Synonyms: Perphenazine, Chlorpiprazin, Chlorpiprozine, Decentan, Fentazin, Neuropax, Perphenan, Perphenazini hydrochloridum, Perphenazine hydrochloride, Trilafon, Trilifan, etc.

Crystal powder, white or white with a barely noticeable grayish tint. Easily soluble in water, little in alcohol. Hygroscopic. Powder and aqueous solutions decompose under the influence of light.

In chemical structure, it differs from meterazine by the presence of a piperazine nucleus of the hydroxyethyl group instead of the methyl group at the 4-position atom of the nitrogen atom.

Etaperazine is an active antipsychotic. It is significantly more active than chlorpromazine in its antiemetic effect and ability to soothe hiccups. It has a muscle-relaxing effect. Slightly less than chlorpromazine potentiates the effect of sleeping pills, drugs and other substances that have a depressing effect on the central nervous system; hypothermic action is expressed in a weak degree; in terms of adrenolytic activity is somewhat inferior to chlorpromazine. It has a cataleptogenic effect.

The strength of antipsychotic action surpasses chlorpromazine and approaches trifthazine. Due to the strong antipsychotic activity, etaperazine may be effective in patients resistant to chlorpromazine. The antipsychotic effect is combined in etaperazine with a pronounced activating effect and selective effect on syndromes that occur with lethargy, lethargy, apathy, primarily with subthoric phenomena, as well as apatoabulic conditions.

Etaperazine can also be used for neurosis accompanied by fear, tension, etc.

One of the important indications for the use of etaperazine is indomitable vomiting and hiccups. As an antiemetic, it is used after surgical interventions on the abdominal organs, during radiation and chemotherapy of malignant neoplasms, etc.

In dermatological practice, it is sometimes prescribed for skin itching.

Etaperazine is prescribed orally in the form of tablets after a meal. Individuals with mental illnesses who have not previously been treated with antipsychotics are given an initial dose of 0.004-0.01 g (4-10 mg) 1-2 times a day. With excitement and a rapid increase in psychotic phenomena, daily doses can reach 30 - 40 mg. In the future, the dose is gradually increased, selecting it individually for each patient. In patients starting treatment with antipsychotics for the first time, the optimal daily dose is usually 50-80 mg (in 2 to 3 doses). For patients with a chronic course of the disease, the daily dose is adjusted to 0.1 - 0.15 g, and in particularly resistant cases to 0.25 - 0.3 g (and sometimes 0.4 g). The duration of treatment is from 1 to 4 months or more. The maintenance therapeutic dose is usually 0.01-0.06 g (10-60 mg) per day.

Treatment with etaperazine can be carried out in combination with other psychotropic drugs.