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Description of the medicine: Frenolon (Frenolon)

Frenolon (Frenolon). 3, 4, 5-Trimethoxybenzoate 2-chloro 10- {3- [1- (b-hydroxyethyl) piperazinyl-4] propyl) -phenothiazine difumarate (or diethanesulfonate).

Synonyms: Metophenazate, Methophenazin, Metofenazatum, Metofenazate, Perphenazintrimethoxybenzoat, Phrenolon, Sylador.

The chemical structure is close to etaperazine. It differs in that the hydroxyethyl radical (- CH 2 - CH 2 -OH) is esterified with the residue of trimethoxybenzoic acid. This acid is a component of reserpine and trioxazine molecules (see).

According to the main pharmacological properties, frenolone is close to chlorpromazine, however, in terms of its therapeutic effect, it has a weakly expressed antipsychotic activity and the presence of a stimulating effect. At the same time it has elements of a sedative effect, but does not cause lethargy, drowsiness, adynamia. In some cases, the use of frenolone euphoric effect.

Prenolone is used in psychiatric practice for stuporous and subthorrhic conditions in periodic and nuclear schizophrenia, as well as for simple and sluggish schizophrenia with apatoabulic syndrome against the background of exacerbation. It is also used for severe neurotic diseases (fear, psychomotor hyperactivity). It can also be prescribed as an antiemetic.

Antipsychotic effect is less pronounced in frenolone than in other phenothiazine preparations. With paranoid schizophrenia with paranoid syndrome, with catatonic agitation, manic state, with hebephrenic schizophrenia, it is ineffective. It does not have the ability to quickly stop psychomotor agitation, even with parenteral administration. In these cases, treatment should be started with other antipsychotic drugs.

The therapeutic effect develops gradually and becomes noticeable 2 to 5 days after the start of treatment.

In depressive conditions within the framework of circular schizophrenia, the use of frenolone can lead to a worsening of the condition with deepening melancholy, the occurrence of insomnia and severe akathisia.

Apply inside and intramuscularly. Assign inside (after eating) 2 to 3 times a day; on the first day, take 0.005 - 0.01 g, on the 2nd - 3rd day, increase the dose to 0.02 - 0.03 g, then to 0.04 - 0.06 g. Therapeutic doses of 0.03 - 0.06 g per day. 5 to 10 mg are administered intramuscularly.

Inpatient treatment usually lasts 1 to 2 months. With subsequent outpatient treatment, 0.02-0.005 g per day is prescribed. Children are prescribed orally at the rate of 1 mg / kg per day (divided into 3 to 5 doses).

The drug is usually well tolerated, including by elderly patients. Possible side effects: insomnia, swelling of the face, dizziness; sometimes a skin rash appears. In rare cases, jaundice, changes in the blood picture, photosensitivity are observed. The most common complications are extrapyramidal disorders with a predominance of akathisia phenomena.

The drug is contraindicated in severe liver and kidney diseases, heart diseases with impaired conduction, endocarditis, blood diseases, depression, pregnancy and lactation.