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Medication Description: Frenolon (Frenolon)

Frenolon (Frenolon). 3, 4, 5-Trimethoxybenzoate 2-chloro 10- {3- [1- (b-hydroxyethyl) piperazinyl-4] -propyl) -phenothiazine difumarate (or diethanesulfonate).

Synonyms: Methophenazate, Methophenazin, Metofenazatum, Metofenazate, Perphenazintrimethoxybenzoat, Phrenolon, Sylador.

The chemical structure is close to epoperazine. It differs in that the hydroxyethyl radical (- CH 2 - CH 2 -OH) is esterified with a residue of trimethoxybenzoic acid. This acid is an integral part of the molecules of reserpine and trioxazine (see).

According to the main pharmacological properties, frenolone is close to chlorpromazine, however, by its therapeutic effect, it has a slightly pronounced antipsychotic activity and the presence of a stimulating effect. At the same time it has elements of sedative action, but does not cause lethargy, drowsiness, adynamia. In some cases, when using frenolone, there is an euphoric effect.

Frenolone is used in psychiatric practice in case of stuporous and sub-acute states in case of periodic and nuclear schizophrenia, as well as in case of simple and sluggish schizophrenia with apatoabulatory syndrome against the background of acute exacerbation. Also used in severe neurotic diseases (fear, psychomotor hyperactivity). May also be prescribed as an antiemetic.

Antipsychotic effect is expressed in frenolone less than that of other phenothiazine drugs. With paranoid schizophrenia with paranoid syndrome, with catatonic agitation, manic state, with hebephrenic schizophrenia it has little effect. Does not have the ability to quickly arrest psychomotor agitation even with parenteral administration. In these cases, treatment should begin with other antipsychotic drugs.

The therapeutic effect develops gradually and becomes noticeable 2 to 5 days after the start of treatment.

In depressive conditions within the framework of circular schizophrenia, the use of frenolone can lead to a deterioration of the condition with deepening melancholy, the appearance of insomnia and severe akathisia.

Apply inside and intramuscularly. Assign inside (after eating) 2 - 3 times a day; on the first day, take 0.005 - 0.01 g, on the 2nd - 3rd day, increase the dose to 0.02 - 0.03 g, then to 0.04 - 0.06 g. Therapeutic doses 0.03 - 0.06 g per day. Intramuscularly administered 5 to 10 mg.

In-patient treatment usually lasts 1–2 months. With subsequent outpatient treatment prescribed by 0.02-0.005 g per day. Children are prescribed orally at the rate of 1 mg / kg per day (divided into 3 - 5 doses).

The drug is usually well tolerated, including in elderly patients. Possible side effects: insomnia, swelling of the face, dizziness; sometimes a skin rash appears. In rare cases, there are jaundice, changes in the blood picture, photosensitivity. The most frequent complications are extrapyramidal disorders with a predominance of akathisia phenomena.

The drug is contraindicated in severe liver and kidney diseases, heart disease with conduction disorders, endocarditis, blood diseases, depression, pregnancy and lactation.