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Description of the medicine: Frenolon (Frenolon)

FRENOLON (Frenolon). 3, 4, 5-Trimethoxybenzoate 2-chloro-10- {3- [1- (b-hydroxyethyl) piperazinyl-4] -propyl) phenothiazine difumarate (or diethanesulfonate).

Synonyms: Methofenazate, Methophenazin, Metofenazatum, Metofenazate, Perphenazintrimethoxybenzoat, Phrenolon, Sylador.

By chemical structure is close to etaperazinu. It differs in that the hydroxyethyl radical (-CH 2 -CH 2 -OH) is esterified with a residue of trimethoxybenzoic acid. This acid is an integral part of reserpine molecules and trioxazine (see).

On the basic pharmacological properties of frenolone is close to the aminazine, but the therapeutic effect is characterized by poorly expressed antipsychotic activity and the presence of a stimulating effect. At the same time it has elements of sedative action, but lethargy, drowsiness, adynamia does not cause. In some cases, when applying frenolone, a euphorizing effect is noted.

Apply frenolone in psychiatric practice with stuporous and sub-stuporous states with periodic and nuclear schizophrenia, as well as with simple and sluggish schizophrenia with apatoabulic syndrome against a sharpened background. Applied also in severe neurotic diseases (fear, psychomotor hyperactivity). Can also be prescribed as an antiemetic.

Antipsychotic effect is expressed in frenolone less than other phenothiazine drugs. In paranoid schizophrenia with paranoia syndrome, with catatonic excitation, manic state, with hebephrenic schizophrenia, it is low-effective. It does not have the ability to quickly stop psychomotor agitation even with parenteral administration. In these cases, treatment should be started with other neuroleptic drugs.

The therapeutic effect develops gradually and becomes noticeable after 2 to 5 days after the start of treatment.

With depressive states in the context of circular schizophrenia, the use of phrenolone can lead to a worsening of the condition with deepening of melancholy, the appearance of insomnia and severe akathisia.

Apply inside and intramuscularly. Assign inside (after eating) 2 - 3 times a day; The first day take 0.005-0.01 g, on the 2nd - 3rd day, increase the dose to 0.02-0.03 g, then to 0.04-0.06 g. Therapeutic doses of 0.03-0.06 G per day. Intramuscularly administered for 5 - 10 mg.

Treatment in a hospital usually lasts 1 to 2 months. At the subsequent out-patient treatment appoint 0,02-0,005 g per day. Children are appointed orally at the rate of 1 mg / kg per day (divide by 3 - 5 receptions).

The drug is usually well tolerated, including elderly patients. Possible side effects: insomnia, swelling of the face, dizziness; Sometimes there is a skin rash. In rare cases, jaundice, changes in blood picture, photosensitivity are observed. The most frequent complications are extrapyramidal disorders with a predominance of akathisia.

The drug is contraindicated in cases of severe liver and kidney disease, heart disease with conduction disorders, endocarditis, blood diseases, depression, pregnancy and lactation.