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Medication Description: Triftazin (Triftazinum)

TRIFTAZIN (Triftazinum). 2-Trifluoromethyl-10- [3- (1-methylpiperazinyl-4) -propyl] phenothiazine dihydrochloride.

Synonyms , Stefan

White or slightly greenish-yellow crystalline powder. Easily soluble in water, soluble in alcohol. In the light darkens.

In terms of chemical structure, triftazine differs from aminazine in that, instead of the chlorine atom in position 2, the phenothiazine nucleus contains the group CFH, and in the side chain it contains the piperazine nucleus substituted at the nitrogen atom in position 4 with the group CH 3 (like in Metarazine).

Triftazin is one of the most active antipsychotic drugs. The neuroleptic effect is combined with a moderate stimulating (energy-stimulating) effect. When hallucinatory and hallucinatory-delusional states manifest sedative effect. The drug has a strong antiemetic effect.

In contrast to aminazine, triftazine has a weak adrenolytic effect. Less potentiates the effect of hypnotic drugs; does not possess antihistamine, spasmolytic and anticonvulsant activity. It has a strong cataleptic effect.

Applied in psychiatric practice for the treatment of schizophrenia, especially paranoid, nuclear and sluggish, with other mental illnesses that occur with delusional symptoms and hallucinations, with involutional psychosis, neurosis and other diseases of the central nervous system.

Triftazin has a more pronounced effect on productive psychotic symptoms (hallucinations, delusions) than aminazin. A distinctive feature of Triftazin is the absence of stiffness, general weakness, stupidity during its use; on the contrary, patients often become more lively, begin to show interest in their surroundings, they are more easily involved in labor processes. In the first days of treatment, drowsiness may occur.

Assign triftazin inside (after eating) and intramuscularly. A single dose when administered at the beginning of treatment is usually 0.005 g (5 mg). Subsequently, the dose is gradually increased by 0.005 g per dose up to a total daily dose of 0.03–0.08 g (in some cases, 0.1–0.12 g per day); The daily dose is divided into 2 - 4 doses. Upon reaching the therapeutic effect, the optimal doses are maintained for 1–3 months, then they are reduced to 0.02–0.005 g per day. These doses are prescribed in the future as maintenance.

Intramuscular injection of Triftazin in cases requiring rapid effect. Initial doses are 0.001 - 0.002 g (1 - 2 mg). Injections are repeated after 4 to 6 hours. The daily dose is usually up to 0.006 g (6 mg), in rare cases up to 0.01 g (10 mg).

In alcoholics, Triftazin is used to treat acute and chronic hallucinatory and delusional psychosis, relieving psychomotor agitation. In acute psychotic conditions, treatment begins with intramuscular injections, turning to ingestion after the removal of acute psychosis.