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Description medications: Triftazin (Triftazinum)

Triftazin (Triftazinum). 2-Trifluoromethyl-10- [3- (1-4-methylpiperazinyl) propyl] -fenotiazina dihydrochloride.

Synonyms: Stelazin, trifluoperazine, Aquil, Calmazine, Clinazine, Equazine , Eskazine, Fluazine, Fluperin, Jatroneural, Modalina, Parstelin, Stelazine, Terfluzine, Trifluoperazini hydrochloridum, Trifluoperazine hydrochloride, Trifluoroperazine, Trifluperazine, Triflurin, Triperazine, Vespezine, Yatroneural and others.

White or slightly greenish-yellow crystalline powder. Easily soluble in water, soluble in alcohol. In the light darkens.

According to the chemical structure of chlorpromazine triftazin it differs in that instead of the chlorine atom in the 2-position of the phenothiazine nucleus contains SFz group and the side chain - piperazine nucleus substituted at the nitrogen atom in the 4-position a group CH 3 (as meterazina).

Triftazin is one of the most active anti-psychotic drugs. Adjunct effect combined with his mild stimulant (energizing) effect. When hallucinatory and hallucinatory-delusional states manifests sedative effect. The drug has a strong anti-emetic effect.

Unlike chlorpromazine triftazin adrenolytic has a weak effect. Less potentiates the effect of hypnotics; It does not possess antihistaminic, antispasmodic and anticonvulsant activity. It has strong cataleptic action.

Apply in psychiatric practice for the treatment of schizophrenia, particularly paranoid, nuclear and indolent, with other mental disorders that occur with delusional symptoms and hallucinations, with involutional psychosis, neurosis and other diseases of the central nervous system.

Triftazin has a more pronounced effect on the productive psychotic symptoms (hallucinations, delusions) than chlorpromazine. Triftazine distinctive feature is the lack of stiffness, general weakness, stupor in its application; Conversely, patients often become more lively, are beginning to show interest in the environment, easier to get involved in the labor process. In the first days of treatment may experience drowsiness.

Triftazin Assign inside (after eating) and intramuscularly. A single dose when administered at the beginning of treatment is usually 0.005 g (5 mg). Further dose gradually increased to 0.005 g per dose for a total daily dose of 0.03 - 0.08 g (in some cases up to 0.1 - 0.12 g per day); daily dose divided into 2 - 4 doses. Upon reaching the optimal therapeutic effect dose is maintained for 1 - 3 months, then they are reduced to 0.02 - 0.005 grams per day. These doses are prescribed to as support.

Intramuscular triftazin administered in cases requiring a rapid effect. The initial dose of 0.001 - 0.002 g (1 - 2 mg). The injections are repeated after 4 -. 6 hours daily dose is generally up to 0,006 g (6 mg) in rare cases - 0.01g (10 mg).

Patients with alcoholism triftazin used for the treatment of acute and chronic hallucinatory and delusional psychosis, agitation relief. For acute psychotic conditions are treated with intramuscular injections, moving to a reception inside after removing the effects of acute psychosis.