This page has been robot translated, sorry for typos if any. Original content here.

Attention! The information is for reference only!
Before taking, be sure to consult a doctor!
SITE ONLY DIRECTORY. NOT A PHARMACY! We do not sell medicines! None!

Description of the medicine: Digitoxin (Digitoxinum)

DIGITOXIN (Digitoxinum).

Glycoside obtained from different types of digitalis (Digitalis purpurea

L., Digitalis lanata Ehrh. and etc.).

Synonyms: Cardigin, Carditoxin, Cordalen, Cristapurat, Cristodigin,

Digimerck, Digitin, Digitoxin, Digitoxinol, Digitoxosidum, Digotin,

Purodigin et al.

White crystalline powder. It is practically insoluble in water, and small in alcohol.

It is the most active digitalis purpurea glycoside; also found in woolly digitalis and in other types of digitalis; 1 g of digitoxin contains 8000 - 10000 ICE or 1911 - 2271 CED. Relatively quickly and almost completely absorbed from the gastrointestinal tract. The effect begins to appear 2 to 4 hours after administration, the maximum effect is observed after 8 to 12 hours. It has a pronounced cumulative effect.

It is prescribed mainly for chronic heart failure, requiring long-term treatment, especially with a tendency to tachycardia.

The dose and duration of treatment should be strictly individual; due to the cumulative properties, side effects characteristic of an overdose can develop relatively easily.

Take digitoxin orally in the form of tablets containing 0.0001 g (0.1 mg) of the drug. Usually they give in the first days 0.6-1.2 mg 'per day (in 4 doses after 6 hours), and the first dose is 1/3 - 1/2 daily (Daily doses sometimes exceed the higher daily doses prescribed by GF. ); when the therapeutic effect is achieved, it is reduced by selecting an individual maintenance dose — usually 0.1-0.06 mg (1-1 / 2 tablets) 1–2 times a day or after 1–2–3 days.

In patients with dyspepsia or stagnation in the portal vein system, digitoxin can be used in the form of suppositories containing 0.00015 g (0.15 mg) of glycoside (Suppositoria Digitoxini 0.00015). Usually injected into the rectum, 1 to 2 suppositories 1 to 2 times a day for the first 2 to 5 days, followed by a decrease in dose to 1 to 2 suppositories per day. In these cases, the dose should also be selected strictly individually.

Higher doses of digitoxin for adults inside: single 0.0005 g (0.5 mg), daily 0.001 g (1 mg).

With the right dose selection, side effects are usually not observed.

With the development of side effects, the dose is reduced, and if necessary, the further administration of the drug is stopped.

Before prescribing digitoxin, it is necessary to find out if the patient received other cardiac glycoside preparations directly before that (last 10-14 days). In these cases, care should be taken to avoid the effects of cumulation. In this regard, a break is necessary (10-14 days) if other cardiac glycosides are prescribed after digitoxin.

Contraindications - see general contraindications for the use of cardiac glycosides.

Method of release: tablets of 0.0001 g (0.1 mg) and suppositories of 0.00015 g (0.15 mg).

Storage: List A. In a cool, dark place.

Rp.: Tab. Digitoxini 0.0001 N.10

DS 1 tablet 1 time per day (for maintenance therapy)

Rp .: Supp. cum Digitoxino 0.00015 N.10

DS