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Description of the medicine: Fluphenazine (Fluphenazine)

FLUFENAZINE (Fluphenazine). 2-Trifluoromethyl-10- {3- [1- (b-hydroxyethyl) -piperazinyl-4] -propyl} phenothiazine dihydrochloride.

Synonyms: Lyogen, Lyorodin, Mirenil, Modithen, Fluorphenazine, Anatensol, Dapotum, Elinol, Flumazine, Flumezin, Fluphenazini hydrochloridum, Fluphenazine hydrochloride, Lyogen, Lyoridin, Mirenil, Moditen, Pacinol, Pacinone, Permitil, Phthorphenazinum, Prolixin, Sevinal, Sevinol, Sevinon, Siqualine, Siqualone, Tensofin, Teviral, Trancin, Vespazin and gp.

It is close in structure to etaperazine, but, like triftazine, contains in group 2 of the phenothiazine nucleus the group CF3. Has a strong neuroleptic and antiemetic activity. In the neurochemical mechanism of the drug's action, a strong blocking effect on central dopamine receptors predominates with moderate effect on noradrenergic receptors.

Fluorphenazine has a strong antipsychotic effect, combined with some activating (energizing) effect. The sedative effect is moderately expressed and is observed at higher doses of the drug.

Fluorphenazine is less active than tryphazine, with delusional and hallucinatory disorders.

Fluorphenazine is used in various forms of schizophrenia, especially in malignant nuclear schizophrenia (hebephrenic, catatonic, early paranoid form), as well as in some forms of periodic schizophrenia (depressive-paranoid, depressive-hypochondriacal states, etc.). The drug is effective in long-term schizophrenia. In small doses can be used in neurotic states, accompanied by fear, stress.

In schizophrenia and other mental illnesses, appoint inward, starting from 0.001 - 0.002 g (1-2 mg) per day and gradually increasing the dose to 10 - 20 30 mg per day (in 3 to 4 doses at intervals of 6 to 8 hours). In especially resistant cases, the daily dose is increased to 40 mg. After the onset of the therapeutic effect, the dose is gradually reduced and switched to maintenance therapy (1 to 5 mg per day).

Intramuscularly, starting with 1, 25 mg (0.5 ml of 0.25% solution), up to 10 mg per day.

At neurotic conditions appoint or nominate inside 1 - 2 mg (up to 3 mg) in day (in 1 - 2 - 3 receptions).

Children's doses are reduced according to age.

In the treatment of fluorophenazine relatively often extrapyramidal disorders can be observed; Can develop convulsive reactions, allergic phenomena.

The drug is not prescribed for acute inflammatory diseases of the liver, diseases of the cardiovascular system with severe decompensation, acute blood diseases, pregnancy and other contraindications to the use of phenothiazine derivatives (see Aminazine).

Forms of release: tablets of 1; 2, 5 and 5 mg; 0.25% solution in ampoules of 1 ml (2, 5 mg).

Storage: List B. In the dark place.

Under the name "Mirenil" abroad fluphenazine dihydrochloride (fluorophenazine) is produced in the form of pills of 0.25 and 1 mg (in a package of 30 pieces); Under the name "Moditen" - in the form of a dragee by 1; 2, 5 and 5 mg (25 and 100 drops in the package) and 0.25% solution in 1 ml ampoules.