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Medication Description: Fluphenazine (Fluphenazine)

Fluphenazine (Fluphenazine). 2-Trifluoromethyl-10- {3- [1- (b -oxyethyl) -piperazinyl-4] -propyl} phenothiazine dihydrochloride.

Synonyms: Lyogen, Lyorodin, Mirenil, Moditen, Fluorophenazine, Anatensol, Dapotum, Elinol, Flumazine, Flumezin, Fluphenazini hydrochloridum, Fluphenazine hydrochloride, Lyogen, Lyoridin, Mirenil, Moditen, Pacinol, Pacinone, Martine, non-alcohol, non-alcohol, non-alcohol, non-alcoholic, non-alcoholic, Citadel, Lyoridin, Fluorzin, Fluorzin, Flumezin, Fluorzin, Fluorzin, Lioridin Sevinon, Siqualine, Siqualone, Tensofin, Teviral, Trancin, Vespazin and gp.

It is similar in structure to ethacterazine, but, like Triftazin, contains in the position 2 of the phenothiazine nucleus the group СFз. It has strong neuroleptic and antiemetic activity. In the neurochemical mechanism of action of the drug, a strong blocking effect on central dopamine receptors prevails with a moderate effect on noradrenergic receptors.

Fluorophenazine has a strong antipsychotic effect, combined with some activating (energizing) effect. Sedative effect is moderate and is observed at higher doses of the drug.

Fluorophenazine is less active than triftazine in delusional and hallucinatory disorders.

Fluorophenazine is used in various forms of schizophrenia, especially in case of malignant nuclear schizophrenia (hebephrenic, catatonic, early paranoid form), as well as in some forms of periodic schizophrenia (deparately paranoid, depressive-hypochondriacal conditions, etc.). The drug is effective in schizophrenia with a long course. In small doses, it can be used for neurotic states accompanied by fear and tension.

In schizophrenia and other mental diseases, it is prescribed by mouth, starting from 0.001 - 0.002 g (1 - 2 mg) per day and gradually increasing the dose to 10 - 20 30 mg per day (in 3 - 4 doses with intervals of 6 - 8 hours). In especially resistant cases, the daily dose is increased to 40 mg. After the onset of the therapeutic effect, the dose is gradually reduced and transferred to maintenance therapy (1–5 mg per day).

Intramuscularly administered, starting with 1, 25 mg (0.5 ml of a 0.25% solution), up to 10 mg per day.

In neurotic conditions, oral administration is 1–2 mg (up to 3 mg) per day (in 1–2–3 doses).

Children dose reduced in accordance with age.

When treatment with fluorophenazine, extrapyramidal disorders are relatively common; convulsive reactions, allergies can develop.

The drug is not prescribed for acute inflammatory diseases of the liver, diseases of the cardiovascular system with severe decompensation, acute blood diseases, pregnancy and other contraindications to the use of phenothiazine derivatives (see Aminazin).

Method of production: tablets of 1; 2, 5 and 5 mg; 0.25% solution in 1 ml ampoules (2, 5 mg).

Storage: List B. In the dark spot.

Under the name << Mirenil >> abroad, fluphenazine (fluorophenazine) dihydrochloride is produced in the form of pills of 0.25 and 1 mg (in a package of 30 pieces); under the name << Moditen >> - in the form of dragees of 1; 2, 5 and 5 mg (25 and 100 tablets in a package) and 0.25% solution in 1 ml ampoules.