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Description medications: Etatsizin (Aethacizinum)

Etatsizin (Aethacizinum). 3 Karbetoksiamino-10- (H-diethylaminopropionyl) -fenotiazina hydrochloride.

The white crystalline powder. Slowly soluble in water, soluble in alcohol.

On chemical structure similar to etmozin. It has antiarrhythmic effect. It refers to antiarrhythmic drugs I group. Lengthen the time of excitation and the duration of the atrial refractory period, atrioventricular node, atrioventricular bundle (bundle of His) and Purkinje fibers.

Apply with ventricular and supraventricular arrhythmias, steam and ksizmalnyh neparoksizmalnyh ventricular and supraventricular tahikar diyah, paroxysms of atrial tachyarrhythmias, including the syndrome of premature ventricular excitation. Assign also in myocardial infarction complicated by heart rhythm disturbances.

Assign inside (regardless of meal times) and intravenously.

Intravenous cupping tachycardia, as well as "alarming" ventricular arrhythmias that require its immediate cancellation.

Inside designate etatsizin, starting with 50 mg three times a day. When untill sufficient effect dose increase (electrocardiographic under control) and 50 mg 4 times daily (200 mg per day) or 100 mg three times daily (300 mg per day). Upon reaching the effect of a supportive therapy in the indie vidually selected minimal doses.

The effect when taking the drug inside is usually manifested in the 1 - 2 Day.

The duration of treatment depends on the type of arrhythmia, efficacy and tolerability.

Administered intravenously at a dose of 0.25 - 1 mg / kg. The contents of one ampoule (2 ml 2, 5% solution = 50 mg) was diluted in 20 ml isotonic sodium chloride solution, and administered slowly (at the rate of 10 mg per minute) under control of BP and ECG. The total dose of 1 mg / kg. Direct injection contains 1 mg of the drug (50 mg) should be continued for at least 5 minutes. The mouth was found that more effective with less side effects (negative inotropic effect) is a drip (50 - 150 mg in a 100 - 200 ml of isotonic sodium chloride solution).

Etatsizin usually more effective than etmozin, but more often causes poboch phenomena. When ingestion possible nausea, dizziness, vio- lated accommodation; when administered intravenously - tinnitus, "numbness" different parts of the body, "grid" in front of his eyes. These events take place after the end of administration.

When using etatsizina should take into account its inhibitory effect on the conducting system of the heart (atrioventricular and intraventricular conduction) and myocardial contractility. The drug can have aritmogen tion action. Perhaps the reduction in coronary blood flow. In the course of treatment must be careful monitoring of the cardiovascular system and the overall condition of the patient.