Description of the medicine: Etatsizin (Aethacizinum)

ETHASYSINE (Aethacizinum). 3-Carbethoxyamino-10- (3-diethylaminopropionyl) phenothiazine hydrochloride.

White crystalline powder. Slowly soluble in water, soluble in alcohol.

The chemical structure is close to ethmosin. Has antiarrhythmic effect. Refers to antiarrhythmic drugs of the I group. Lengthens the time of excitation and duration of refractory periods of the atria, atrioventricular node, atrioventricular bundle (bundle of His) and fibers Purkinje.

Applied with ventricular and supraventricular extrasystoles, paroxysmal and non-paroxysmal ventricular and supraventricular tachycardia, paroxysms of atrial tachyarrhythmia, including in the syndrome of premature ventricular excitation. Assign also with myocardial infarction, complicated by heart rhythm disturbances.

Assign inside (regardless of the time of ingestion) and intravenously.

Intravenously injected for relief of attacks of tachycardia, as well as with "menacing" ventricular extrasystole, when immediate suppression is required.

Inside prescribe etatsizin, starting with 50 mg 3 times a day. If the effect is not enough, the dose is increased (under electrocardiographic control) to 50 mg 4 times a day (200 mg per day) or 100 mg three times a day (300 mg per day). When the effect is achieved, supportive therapy is carried out in individually selected minimum doses.

The effect of taking the drug inside usually appears on the 1st - 2nd day.

The duration of treatment depends on the form of arrhythmia, the effectiveness of therapy and the tolerability of the drug.

Intravenously injected at a dose of 0.25 - 1 mg / kg. The contents of one ampoule (2 ml of 2, 5% solution = 50 mg) are diluted in 20 ml of isotonic sodium chloride solution and administered slowly (at the rate of 10 mg of drug per minute) under the control of blood pressure and ECG. The total dose is up to 1 mg / kg. The administration of 1 ampoule of the drug (50 mg) should be continued for at least 5 minutes. It has been established that drip administration (50-150 mg per 100-200 ml of isotonic sodium chloride solution) is more effective with less adverse effects (negative inotropic effect).

Etatsizin usually more effective than ethmosin, but more often causes side effects. When ingestion, nausea, dizziness, disruption of accommodation are possible; At intravenous introduction - a noise in ears, "numbness" of different parts of a body, "a grid" before eyes. These phenomena pass after the end of the introduction.

When using etatsizina should take into account its inhibitory effect on the conduction system of the heart (atrioventricular and intragastric conduction) and myocardial contractility. The drug may have arrhythmogenic effect. It is possible to reduce coronary blood flow. In the process of treatment, careful monitoring of the cardiovascular system and the general condition of the patient is necessary.