Description of the medicine: Nitrosorbidum (Nitrosorbidum)
NITROSORBIDE (Nitrosorbidum). 1, 4, 3, 6-Dianhydro-D-sorbitol dinitrate.
Synonyms: Isoket, Izodinit, Kornilat, Lomilan, Armadan, Carvanil, Carvasin, Cornilat, Corodil, Coronex, Difutrat, Isodinit, Isodril, Isoket, Isonit, Isorbid, Isosorbide dinitrate, Isosorbidi dinitras, Isotrate, Nomilanidronidronidomidronidromidan Risordan, Sorbangil, Sorbidilat, Vascardyn, Vasodilat, Vasorbate, etc.
White crystalline powder. It is practically insoluble in water, it is difficult in alcohol.
Nitrosorbide is one of the main antianginal organic nitrates for oral use. In the form of special dosage forms is available for sublingual, intravenous and inhalation use.
When taken orally in the form of tablets, the onset of action of nitrosorbide is noted after 30 - 50 minutes, the maximum effect - after 1, 5 - 2 hours, the total duration of action - 4 - 6 hours or more.
Nitrosorbide is widely prescribed as an antianginal agent in the chronic course of IHD to prevent attacks; with infrequent attacks of stable angina pectoris. Take before meals, usually 0.005 - 0.01 g (5 - 10 mg) 3-4 times a day. Sometimes patients require higher single doses (20-30 mg) (According to existing data, in order to avoid the development of tolerance, it is advisable to take nitrosorbide 30 mg 2 times a day: at 8 a.m. and 1 p.m., i.e. "the period of greatest physical activity. From 13 p.m. to 8 p.m. the next morning, sensitivity to the drug is restored.).
Applied sublingually (in the form of conventional tablets) nitrosorbide can stop an attack of angina pectoris, but more slowly than nitroglycerin (after 3 - 5 minutes).
In recent years, nitrosorbide, like nitroglycerin, began to be used as a peripheral vasodilator in severe forms of heart failure. Reducing the tone of peripheral venous vessels (venules), the drug reduces venous blood flow to the heart, pressure in the vessels of the small circle, shortness of breath, suffocation, cyanosis. It is taken orally at 20 mg (2 tablets) every 4 to 5 hours.
Sometimes prescribed for endarteritis and other diseases, accompanied by spasms of peripheral vessels.
Possible side effects: headache, dizziness, nausea pass with a decrease in dose.
Contraindications are the same as for nitroglycerin.
With prolonged use of nitrosorbide, tolerance may develop, and therefore it is recommended after 3 to 6 weeks of regular tablets to take a break for 3 to 5 days, replacing nitrosorbide with other antianginal drugs.
Release form: tablets on 0,005; 0.01 and 0.02 g (5, 10 and 20 mg).
Storage: List B. In a dry, cool, dark place away from fire.
Izodinit (Bulgaria) is available in the form of tablets: for oral administration (10 mg each); sublingual tablets (2.5 mg of isosorbide dinitrate per tablet), chewable tablets (10 mg per tablet) and isodinite retard tablets (20 mg per tablet), as well as a 0.1% injection solution in 10 ml vials (10 mg).
In addition, medicinal aerosol forms of Isomac-spray nitrosorbide (Isomac-spray) and others are produced abroad.