Medication Description: Nitrosorbid (Nitrosorbidum)
NITROSORBID (Nitrosorbidum). 1, 4, 3, 6-Dianhydro-D-sorbitol dinitrate.
Synonyms: Isoket, Izodinit, Kornilat, Lomilan, Armadan, Carvanil, Cornilat, Corodil, Coronex, Difutrat, Isodinit, Isodril, Isoket, Isonit, Isorbid, Isosorbide dinitrate, Isosorbidi dinitras, Isotstit, Isorbid, Isosorbide dinitrate, Isosorbidi dinitras, Isotrits, Isorbid, Isosorbide dinitrate Risordan, Sorbangil, Sorbidilat, Vascardyn, Vasodilat, Vasorbate, etc.
White fine crystalline powder. Practically insoluble in water, it is difficult - in alcohol.
Nitrosorbid is one of the main antianginal organic nitrates for oral administration. In the form of special dosage forms available for sublingual, intravenous and inhalation use.
When administered in the form of tablets, the onset of action of nitrosorbide is noted after 30 - 50 minutes, the maximum effect - after 1, 5 - 2 hours, the total duration of action - 4 - 6 hours or more.
Nitrosorbid is widely prescribed as an antianginal agent in the chronic course of IHD to prevent seizures; with infrequent bouts of stable angina. It is usually taken in 0.005-0.01 g (5-10 mg) 3 to 4 times a day before meals. Sometimes patients require higher single doses (20 -30 mg) (According to existing data, in order to avoid the development of tolerance, it is advisable to take nitrosorbid 30 mg 2 times a day: at 8 am and 13 hours, i.e. "the period of the greatest physical activity. From 13 h to 8 h the next morning, sensitivity to the drug is restored.).
Applied sublingually (in the form of conventional tablets) nitrosorbid can stop an angina attack, but more slowly than nitroglycerin (after 3-5 minutes).
In recent years, nitrosorbid, like nitroglycerin, has been used as a peripheral vasodilator in severe forms of heart failure. Reducing the tone of peripheral venous vessels (venules), the drug reduces venous blood flow to the heart, blood pressure in the small circle, shortness of breath, asphyxiation, cyanosis. Take it inside by 20 mg (2 tablets) every 4 to 5 hours.
Sometimes prescribed for endarteritis and other diseases, accompanied by spasms of peripheral vessels.
Possible side effects: headache, dizziness, nausea pass away with a decrease in dose.
Contraindications are the same as for nitroglycerin.
With prolonged use of nitrosorbide, tolerance may develop, and therefore it is recommended after 3–6 weeks of regular use of tablets to take a break for 3–5 days, replacing this time with nitrosorbid with other antianginal drugs.
Form release: pills to 0,005; 0.01 and 0.02 g (5, 10 and 20 mg).
Storage: List B. In a dry, cool, dark place far from fire.
Izodinit (Bulgaria) is available in the form of tablets: for oral administration (10 mg each); sublingual tablets (2, 5 mg of isosorbide dinitrate per tablet), chewable tablets (10 mg per tablet) and izodinit retard tablets (20 mg per tablet), as well as 0.1% solution for injection in 10 ml bottles (10 mg).
In addition, medicinal aerosol forms of nitrosorbide "Isomac-spray" (Isomac-spray) and others are produced abroad.