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Description of the medicine: Nonachlazinum (Nonachlazinum)

NONAXLAZIN (Nonachlazinum). 2-Chloro-10- {3- [1, 4-diazabicyclo [4, 3, 0] -nonanyl-4] -propionyl} phenothiazine dihydrochloride.

White with a creamy shade of crystalline powder. Soluble in water, very little in alcohol; PH 1, 5% solution 2, 3 - 2, 8.

By chemical structure refers to the propionyl derivatives of phenothiazine (Close to nonachalazine by structure and action, coronary dilatant chloracycin is excluded from the nomenclature of drugs as a low-active drug.) (See also Ethmosin, Etatsizin); In the side chain contains a nitrogen-containing bicyclic system. In contrast to chlorpromazine and fluocyclin does not have neuroleptic or antidepressant effects.

Nonahlazin improves blood flow to the heart by increasing coronary blood flow. The drug increases the oxygen reserve of the myocardium. In this case, the contractility of the myocardium increases without significant changes in cardiac output and heart function.

The mechanism of action of nonahlazine has not been sufficiently studied. A certain role is played by its adrenostimulating properties (see also Oxyphedrine).

Applied with CHD (angina pectoris tension and rest, as well as with angina pectoris against a background of acute or acute myocardial infarction). To prevent attacks, angina pectoris is taken orally in the form of tablets or a solution, and for relief of attacks - only in the form of a solution. When administered orally in the form of a solution, nonahlazine is rapidly absorbed.

For relief of seizures, nonahlazine is used in patients who do not tolerate nitroglycerin or who have contraindications to its use. Nonahlazin in solution, in contrast to nitroglycerin, does not lower blood pressure and does not cause dizziness, but often nitroglycerin more effectively eliminates an attack than nonahlazine.

For the course treatment of chronic ischemic heart disease, tablets are prescribed 0.03 g (1 tablet) for 1 hour before meals 3 to 4 times a day. The daily dose can be increased to 0.18 - 0.24 g. The course of treatment continues on average 3 - 4 weeks. 3 to 4 days before the end of treatment, the dose is gradually reduced.

In pre-infarcted condition, it is recommended to begin treatment with oral administration of 5 ml (1 teaspoon) of 1, 5% solution 3 times a day (at regular intervals) for 3 days, then switch to taking tablets (1 tablet 4-8 times a Day for 3 to 4 weeks). A solution of nonahlazine is taken on an empty stomach without washing with water or other liquid. You can also use nonahlazine tablets under the tongue, after having chewed them.

For relief of attacks of angina pectoris, take 5-10 ml (1 - 2 teaspoons) of 1, 5% solution inside. If necessary, repeat the reception of the drug with a break of 4 - 5 hours, not exceeding the total daily dose of ZO ml. If the attack occurred earlier than 4 hours after taking nonahlazina, the attack should be stopped with nitroglycerin.

If attacks of angina can not be stopped with nonahlazine, you should switch to other antianginal drugs.

In large doses, nonahlazine can cause a drop in blood pressure and a headache.