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Description of the medicine: Oxyphedrine (Oxyfedrinum)

OXYFEDRINUM.

DL-3- (b-Oxy-a-methylphenethylamino) -3'-methoxypropiophenone hydrochloride.

Synonyms: Ildamen, Myofedrine, Ildamen, Myofedrin, Oxifedrin.

Chemically belongs to the group of phenylalkylamines and is structurally derived from ephedrine (see), from which it differs by the presence of a methoxypropiophenone group instead of a methyl group at the nitrogen atom of the amino group.

The drug has partial agonistic activity in relation to β-adrenoreceptors of the heart, has a direct coronary expansive effect, increases the contractile ability of the myocardium without an excessive increase in oxygen demand.

Indications for use: angina pectoris (with infrequent attacks) with bradycardia.

Assign inside 8 mg (0.008 g) 3 times a day, with insufficient effect - 16 mg (up to 32 mg) 3 times a day.

Contraindications: aortic insufficiency with the phenomena of circulatory disturbance, subaortic stenosis. As shown by experimental data, oxyphedrine under certain conditions can have a direct inhibitory effect on the myocardium, which may be due to blockade of β-adrenoreceptors.

Form release: tablets of 0.008 and 0.016 g (8 and 16 mg).